A rare cause of acute pulmonary oedema
| Autor: | William Drake, Umasuthan Srirangalingam, Samir A Khwaja |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Pulmonary Circulation Congenital mitral stenosis medicine.medical_specialty Ganglionic Blockers Adrenal Gland Neoplasms Pulmonary Edema Paraganglioma Mitral valve stenosis Internal medicine medicine Palpitations Animals Humans Mitral Valve Stenosis Hypoxia Acute Medical Care Lung Acute pulmonary oedema Morphine business.industry Respiration Frothy sputum Isoproterenol Muscle Smooth General Medicine medicine.disease Pulmonary edema Surgery Oxygen Pulmonary Alveoli Radiography Carotid Arteries Cats Cardiology Female medicine.symptom business Dihydroergotamine Procaine |
| Zdroj: | Clinical medicine (London, England). 12(6) |
| ISSN: | 1470-2118 |
| Popis: | In acute experiments on 92 cats anesthetized with Urethane and kept under controlled respiration the mechanism of tonic activity of the pulmonary vessels was studied in the presence of a decreased partial pressure of oxygen in the alveoli. The tonicity of the pulmonary vessels was recorded during autoperfusion of the vessels of the posterior lobe of the left lung by means of a perfusion pump. Simultaneously, the pressure in the common carotid artery was recorded and the oxygen saturation of the blood was measured. Pharmacological analysis was used for the study of the mechanism of the pressor reaction of the pulmonary vessels under hypoxic hypoxy, and it demonstrated that the pression of the pulmonary vessels that develops under alveolar hypoxy is less distinct under the effect of the ganglioblocking agent Benzo-hexonium, as well as the myotropic agents Papaverine and Chloracizine. The above reaction was significantly inhibited by the blocking agents of the D- and M-serotonin-reactive structures -- Dihydroergothamine, Morphine and Novocain, and it was completely lacking against the background of the action of Izadrine and Dimedrol -- blocking agents of serotonin- and histamine-reactive structures. It can be supposed that the D- and M-serotonin-reactive, and probably also the histamine-reactive structures participate in the regulation of the interrelationship of ventilation and pulmonary circulation. |
| Databáze: | OpenAIRE |
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