ROS homeostasis and metabolism: a critical liaison for cancer therapy
Autor: | Jong-Sup Bae, Jaehong Kim, Jongdoo Kim |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Clinical Biochemistry Antineoplastic Agents Disease Review Biology Carbohydrate metabolism medicine.disease_cause Biochemistry 03 medical and health sciences Neoplasms medicine Tumor Microenvironment Animals Homeostasis Humans Molecular Targeted Therapy Molecular Biology Tumor microenvironment food and beverages Hypoxia (medical) Cell biology Metabolic pathway Oxidative Stress 030104 developmental biology Glucose Cancer cell Molecular Medicine medicine.symptom Stem cell Reactive Oxygen Species Oxidation-Reduction Oxidative stress Metabolic Networks and Pathways |
Zdroj: | Experimental & Molecular Medicine |
ISSN: | 2092-6413 1226-3613 |
Popis: | Evidence indicates that hypoxia and oxidative stress can control metabolic reprogramming of cancer cells and other cells in tumor microenvironments and that the reprogrammed metabolic pathways in cancer tissue can also alter the redox balance. Thus, important steps toward developing novel cancer therapy approaches would be to identify and modulate critical biochemical nodes that are deregulated in cancer metabolism and determine if the therapeutic efficiency can be influenced by changes in redox homeostasis in cancer tissues. In this review, we will explore the molecular mechanisms responsible for the metabolic reprogramming of tumor microenvironments, the functional modulation of which may disrupt the effects of or may be disrupted by redox homeostasis modulating cancer therapy. |
Databáze: | OpenAIRE |
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