Increased Risk of Parkinson's Disease in Patients With Schizophrenia Spectrum Disorders
| Autor: | Jarmo Hietala, Valtteri Kaasinen, Samu Kurki, Tomi Kuusimäki, Haidar Al-Abdulrasul, Marjaana Koponen, Anna-Maija Tolppanen, Sirpa Hartikainen |
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| Přispěvatelé: | Neurologian yksikkö, Department of Neurosciences, University of Helsinki, HUS Neurocenter |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Psychosis medicine.medical_specialty Paranoid schizophrenia Movement disorders Parkinson's disease SYMPTOMS 3124 Neurology and psychiatry s disease 03 medical and health sciences 0302 clinical medicine PSYCHOSIS Internal medicine mental disorders medicine Humans EXPOSURE Clozapine Finland Retrospective Studies RELEASE HYPOTHESIS business.industry MORTALITY 3112 Neurosciences Parkinson Disease Odds ratio Parkinson&apos medicine.disease Comorbidity 3. Good health comorbidity 030104 developmental biology Neurology Schizophrenia Case-Control Studies PRESYNAPTIC DOPAMINE FUNCTION Neurology (clinical) medicine.symptom dopamine CLOZAPINE business 030217 neurology & neurosurgery PARANOID SCHIZOPHRENIA medicine.drug |
| Zdroj: | Movement disorders : official journal of the Movement Disorder SocietyReferences. 36(6) |
| ISSN: | 1531-8257 2004-2019 |
| Popis: | BACKGROUND PD comorbid with schizophrenia has been considered rare because these diseases associate with opposite alterations in the brain dopamine system. The objective of this study was to investigate the risk of PD after a diagnosis of a schizophrenia spectrum disorder. METHODS Regionally, this was a retrospective record-based case-control study. The cohort included 3045 PD patients treated 2004-2019 in southwestern Finland. Nationally this was a nested case-control study using registers to examine Finnish patients who received a clinically confirmed PD diagnosis 1996-2015 (n = 22,189). PD patients with previously diagnosed schizophrenia spectrum disorder (separate analysis for schizophrenia) were included. Comparable non-PD control groups were derived from both data sets. All PD diagnoses were based on individual clinical examinations by certified neurologists. RESULTS In PD patients, the prevalence of earlier schizophrenia spectrum disorder was 0.76% in regional data and 1.50% in nationwide data. In age-matched controls, the prevalence in the regional and national data was 0.16% and 1.31%, respectively. The odds ratio for PD after schizophrenia spectrum disorder diagnosis was 4.63 (95% CI, 1.76-12.19; P |
| Databáze: | OpenAIRE |
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