Identification of Vaginal Microbial Communities Associated with Extreme Cervical Shortening in Pregnant Women
| Autor: | Monica Di Paola, Viola Seravalli, Francesco Vitali, Carlotta Linari, Mariarosaria Di Tommaso, Maria Torcia, Michele Tanturli, Astrid Parenti, Carlotta De Filippo, Sara Paccosi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
shortened cervix
Physiology microbiome lcsh:Medicine high-risk pregnancy Article 03 medical and health sciences 0302 clinical medicine Lactobacillus medicine Microbiome 030304 developmental biology 0303 health sciences Pregnancy 030219 obstetrics & reproductive medicine biology business.industry Metabolic disorder lcsh:R Gestational age General Medicine Odds ratio medicine.disease biology.organism_classification Gestational diabetes Anaerobic bacteria business Microbiota pregnancy short cervix |
| Zdroj: | Journal of Clinical Medicine, Vol 9, Iss 3621, p 3621 (2020) Journal of clinical medicine 9 (2020): 3621. doi:10.3390/jcm9113621 info:cnr-pdr/source/autori:Di Paola, Monica; Seravalli, Viola; Paccosi, Sara; Linari, Carlotta; Parenti, Astrid; De Filippo, Carlotta; Tanturli, Michele; Vitali, Francesco; Torcia, Maria Gabriella; Di Tommaso, Mariarosaria/titolo:Identification of Vaginal Microbial Communities Associated with Extreme Cervical Shortening in Pregnant Women/doi:10.3390%2Fjcm9113621/rivista:Journal of clinical medicine/anno:2020/pagina_da:3621/pagina_a:/intervallo_pagine:3621/volume:9 Journal of Clinical Medicine Volume 9 Issue 11 |
| DOI: | 10.3390/jcm9113621 |
| Popis: | The vaginal microbiota plays a critical role in pregnancy. Bacteria from Lactobacillus spp. are thought to maintain immune homeostasis and modulate the inflammatory responses against pathogens implicated in cervical shortening, one of the risk factors for spontaneous preterm birth. We studied vaginal microbiota in 46 pregnant women of predominantly Caucasian ethnicity diagnosed with short cervix (< 25 mm), and identified microbial communities associated with extreme cervical shortening (&le 10 mm). Vaginal microbiota was defined by 16S rRNA gene sequencing and clustered into community state types (CSTs), based on dominance or depletion of Lactobacillus spp. No correlation between CSTs distribution and maternal age or gestational age was revealed. CST-IV, dominated by aerobic and anaerobic bacteria different than Lactobacilli, was associated with extreme cervical shortening (odds ratio (OR) = 15.0, 95% confidence interval (CI) = 1.56&ndash 14.21 p = 0.019). CST-III (L. iners-dominated) was also associated with extreme cervical shortening (OR = 6.4, 95% CI = 1.32&ndash 31.03 p = 0.02). Gestational diabetes mellitus (GDM) was diagnosed in 10/46 women. Bacterial richness was significantly higher in women experiencing this metabolic disorder, but no association with cervical shortening was revealed by statistical analysis. Our study confirms that Lactobacillus-depleted microbiota is significantly associated with an extremely short cervix in women of predominantly Caucasian ethnicity, and also suggests an association between L. iners-dominated microbiota (CST III) and cervical shortening. |
| Databáze: | OpenAIRE |
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