Effect of the rigid segment content on the properties of segmented polyurethanes conjugated with atorvastatin as chain extender
| Autor: | Guido Antonio Zapata-Catzin, Juan V. Cauich-Rodríguez, L. H. Chan-Chan, Assunta Borzacchiello, Humberto Vázquez-Torres, Efrén Hernández-Baltazar, R.F. Vargas-Coronado, José M. Cervantes-Uc, Marcos Bonilla-Hernández |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
Nonlinear Optical Microscopy Spectrophotometry Infrared Biocompatibility Cell Survival Polyesters Polyurethanes Diol Biomedical Engineering Biophysics Biocompatible Materials Bioengineering segmentes polyurethans 02 engineering and technology 010402 general chemistry 01 natural sciences Cell Line Biomaterials Mice chemistry.chemical_compound Crystallinity Atorvastatin Animals Fourier transform infrared spectroscopy Cyanates chemistry.chemical_classification Molecular Structure Temperature Polymer 021001 nanoscience & nanotechnology Isocyanate 0104 chemical sciences chemistry Polycaprolactone lipids (amino acids peptides and proteins) 0210 nano-technology Glass transition Nuclear chemistry |
| Zdroj: | Journal of materials science. Materials in medicine 29 (2018). doi:10.1007/s10856-018-6165-y info:cnr-pdr/source/autori:Zapata-Catzin, Guido A.; Bonilla-Hernandez, Marcos; Vargas-Coronado, Rossana F.; Cervantes-Uc, Jose M.; Vazquez-Torres, Humberto; Hernandez-Baltazar, Efren; Chan-Chan, Lerma H.; Borzacchiello, Assunta; Cauich-Rodriguez, Juan V./titolo:Effect of the rigid segment content on the properties of segmented polyurethanes conjugated with atorvastatin as chain extender/doi:10.1007%2Fs10856-018-6165-y/rivista:Journal of materials science. Materials in medicine/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:29 |
| ISSN: | 1573-4838 0957-4530 |
| Popis: | Segmented polyurethanes were prepared with polycaprolactone diol as soft segment and various amounts of 4,4 '-Methylenebis(cyclohexyl isocyanate) and atorvastatin, a statin used for lowering cholesterol, in order to obtain SPU with different content of rigid segments. Polyurethanes with 35% or 50% of rigid segment content were physicochemically characterized and their biocompatibility assessed with L929 fibroblasts. High concentrations of atorvastatin were incorporated by increasing the content of rigid segments as shown by FTIR, Raman, NMR, XPS and EDX. Thermal and mechanical characterization showed that polyurethanes containing atorvastatin and 35% of rigid segments were low modulus (13MPa) semicrystalline polymers as they exhibited a glass transition temperature (T-g) at -38 degrees C, melting temperature (T-m) at 46 degrees C and crystallinity close to 35.9% as determined by DSC. In agreement with this, X-ray diffraction showed reflections at 21.3 degrees and 23.6 degrees for PCL without reflections for atorvastatin suggesting its presence in amorphous form with higher potential bioavailability. Low content of rigid segments led to highly degradable polymer in acidic, alkaline and oxidative media with an acceptable fibroblast cytotoxicity up to 7 days possibly due to low atorvastatin content. |
| Databáze: | OpenAIRE |
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