Peromyscus as a model of human disease
| Autor: | Hippokratis Kiaris, Janet P. Crossland, Amanda Havighorst |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
endocrine system Aging Peromyscus Carcinogenesis animal diseases ved/biology.organism_classification_rank.species Biology 03 medical and health sciences Human disease parasitic diseases Animals Humans Genus Peromyscus Model organism Hypoxia ved/biology Cell Biology Limiting biology.organism_classification Adaptation Physiological Review article Disease Models Animal 030104 developmental biology Evolutionary biology Immunology Developmental Biology |
| Zdroj: | Seminars in celldevelopmental biology. 61 |
| ISSN: | 1096-3634 |
| Popis: | Animals of the genus Peromyscus have been a particularly informative model for many areas of study, including behavior, evolution, anatomy, physiology and genetics. While their use in modeling human disease and pathology has been relatively restricted, certain qualities of Peromyscine mice may make them a good candidate for such studies. Pathophysiological conditions where Peromyscus may be of particular value involve aging, reactive oxygen species-associated pathologies, metabolism and detoxification, diabetes, and certain cancers. In this review article we will summarize pathological conditions where Peromyscus have been used effectively, we will discuss factors limiting the use of Peromyscus in studying pathology and we will indicate areas at which the use of this model may be of special value. |
| Databáze: | OpenAIRE |
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