Suppression of interictal spikes during phasic rapid eye movement sleep: a quantitative stereo-electroencephalography study

Autor: Campana C. 1, 2, Zubler F. 1, Gibbs S. 1, 3, de Carli F. 4, Proserpio P. 1, Rubino A. 1, Cossu M. 1, Tassi L. 1, Schindler K. 5, Nobili L. 1.
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
interictal epileptiform discharges
Cognitive Neuroscience
Rapid eye movement sleep
Sleep
REM
Epilepsies
Electroencephalography
Hippocampus
Non-rapid eye movement sleep
Tonic (physiology)
03 medical and health sciences
Behavioral Neuroscience
Epilepsy
0302 clinical medicine
Seizures
mental disorders
Group I
medicine
Humans
Ictal
tonic REM sleep
epilepsy
phasic REM sleep
stereo-EEG
synchronization
Brain
Epilepsies
Partial
Female
Malformations of Cortical Development
Group I
Hippocampal sclerosis
medicine.diagnostic_test
business.industry
musculoskeletal
neural
and ocular physiology
Eye movement
General Medicine
medicine.disease
Malformations of Cortical Development
030104 developmental biology
REM
Sleep
business
Neuroscience
psychological phenomena and processes
030217 neurology & neurosurgery
Partial
Zdroj: Journal of sleep research (Online) 26 (2017): 606–613. doi:10.1111/jsr.12533
info:cnr-pdr/source/autori:Campana C. 1,2, Zubler F. 1, Gibbs S. 1,3, de Carli F. 4, Proserpio P. 1, Rubino A. 1,2, Cossu M. 1, Tassi L. 1, Schindler K. 5, Nobili L. 1./titolo:Suppression of interictal spikes during phasic rapid eye movement sleep: a quantitative stereo-electroencephalography study./doi:10.1111%2Fjsr.12533/rivista:Journal of sleep research (Online)/anno:2017/pagina_da:606/pagina_a:613/intervallo_pagine:606–613/volume:26
ISSN: 0962-1105
DOI: 10.1111/jsr.12533
Popis: Tonic and phasic rapid eye movement (REM) sleep seem to represent two different brain states exerting different effects on epileptic activity. In particular, interictal spikes are suppressed strongly during phasic REM sleep. The reason for this effect is not understood completely. A different level of synchronization in phasic and tonic REM sleep has been postulated, yet never measured directly. Here we assessed the interictal spike rate across non-REM (NREM) sleep, phasic and tonic REM sleep in nine patients affected by drug resistant focal epilepsy: five with type II focal cortical dysplasia and four with hippocampal sclerosis. Moreover, we applied different quantitative measures to evaluate the level of synchronization at the local and global scale during phasic and tonic REM sleep. We found a lower spike rate in phasic REM sleep, both within and outside the seizure onset zone. This effect seems to be independent from the histopathological substrate and from the brain region, where epileptic activity is produced (temporal versus extra-temporal). A higher level of synchronization was observed during tonic REM sleep both on a large (global) and small (local) spatial scale. Phasic REM sleep appears to be an interesting model for understanding the mechanisms of suppression of epileptic activity.
Databáze: OpenAIRE
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