The effect of effort-reward imbalance on brain structure and resting-state functional connectivity in individuals with high levels of schizotypal traits
| Autor: | Raymond C.K. Chan, Yong jie Yan, Simon S.Y. Lui, Kristoffer Hougaard Madsen, Jia Huang, Eric F.C. Cheung |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Cognitive Neuroscience Population Schizotypal Personality Disorder 03 medical and health sciences 0302 clinical medicine Reward Surveys and Questionnaires medicine Humans education Cerebral Cortex education.field_of_study Resting state fMRI Functional connectivity Brain Voxel-based morphometry medicine.disease 030227 psychiatry Effort reward imbalance Psychiatry and Mental health Schizophrenia Psychosocial stress Female Psychology 030217 neurology & neurosurgery Clinical psychology Personality |
| Zdroj: | Cognitive neuropsychiatry. 26(3) |
| ISSN: | 1464-0619 |
| Popis: | Effort-reward imbalance (ERI) is a typical psychosocial stress. Schizotypal traits are attenuated features of schizophrenia in the general population. According to the diathesis-stress model, schizotypal traits and psychosocial stress contribute to the onset of schizophrenia. However, few studies examined the effects of these factors on brain alterations. This study aimed to examine relationships between ERI, schizotypal traits and brain structures and functions.We recruited 37 (13 male, 24 female) participants with high levels of schizotypal traits and 36 (12 male, 24 female) participants with low levels of schizotypal traits by the Schizotypal Personality Questionnaire (SPQ). The Chinese school version of the effort-reward imbalance questionnaire (C-ERI-S) was used to measure ERI. We conducted the voxel-based morphometry (VBM) and whole brain resting-state functional connectivity (rsFC) analysis using reward or stress-related regions as seeds.Participants with high levels of schizotypal traits were more likely to perceive ERI. The severity of ERI was correlated with grey matter volume (GMV) reduction of the left pallidum and altered rsFC among the prefrontal, striatum and cerebellum in participants with high levels of schizotypal traits.ERI is associated with GMV reduction and altered rsFC in individuals with high levels of schizotypal traits. |
| Databáze: | OpenAIRE |
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