Modulation of Leptin Levels by Oxidized Linoleic Acid: A Connection to Atherosclerosis?
| Autor: | Nadya Merchant, Sampath Parthasarathy, Meera Penumetcha |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Leptin
Male medicine.medical_specialty Linoleic acid Short Communications Medicine (miscellaneous) medicine.disease_cause Cholesterol Dietary Linoleic Acid Lipid peroxidation Mice chemistry.chemical_compound medicine.artery Internal medicine medicine Animals Obesity Receptor Aorta Triglycerides Mice Knockout Nutrition and Dietetics business.industry Cholesterol LDL Atherosclerosis medicine.disease Lipoproteins LDL Oxidative Stress Endocrinology Receptors LDL chemistry Lipid Peroxidation business Oxidative stress Lipoprotein |
| Zdroj: | Journal of Medicinal Food. 14:441-443 |
| ISSN: | 1557-7600 1096-620X |
| Popis: | The objective of the study was to determine the effects of oxidized linoleic acid (Ox-LA) on plasma leptin and to determine the relationship between plasma leptin levels and atherosclerosis in animals treated with Ox-LA. Low-density lipoprotein (LDL) receptor knockout (LDL r(-/-)) mice were fed a high fat diet with or without Ox-LA for 11 weeks. Plasma leptin levels in the high fat group consuming Ox-LA were significantly higher (14,052 ± 601 pg/mL vs. 10,950 ± 541 pg/mL; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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