Bacterial Translocation Associates With Aggression in Schizophrenia Inpatients
| Autor: | Teng Zhang, Chong Wang, Ji-Yong Fu, Bang-Tao Chen, Lei He, Xiao-Ling Xue, Hong-Xin Deng |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cognitive Neuroscience
CD14 Neuroscience (miscellaneous) Neurosciences. Biological psychiatry. Neuropsychiatry Inflammation Cellular and Molecular Neuroscience Developmental Neuroscience Medicine bacterial translocation Modified Overt Aggression Scale Original Research business.industry Aggression aggression association Interleukin medicine.disease Discontinuation schizophrenia inflammation Schizophrenia Immunology Tumor necrosis factor alpha medicine.symptom business RC321-571 Neuroscience |
| Zdroj: | Frontiers in Systems Neuroscience Frontiers in Systems Neuroscience, Vol 15 (2021) |
| ISSN: | 1662-5137 |
| DOI: | 10.3389/fnsys.2021.704069 |
| Popis: | Objective: Accumulating evidence indicates that inflammation abnormalities may contribute to aggression behaviors in psychotic patients, however, the possible sources of inflammation remain elusive. We aimed to evaluate the associations among aggression, inflammation, and bacterial translocation (BT) in aggression-affected schizophrenia (ScZ) inpatients with 2 weeks of antipsychotics discontinuation.Methods: Serum specimens collected from 112 aggression and 112 non-aggression individuals with ScZ and 56 healthy adults were used for quantifications of inflammation- or BT-related biomarkers. Aggression severity was assessed by Modified Overt Aggression Scale (MOAS).Results: Proinflammation phenotype dominated and leaky gut-induced BT occurred only in cases with ScZ with a history of aggression, and the MOAS score positively related to levels of C-reactive protein, interleukin (IL)-6, IL-1β, and tumor necrosis factor-α. Furthermore, serum levels of BT-derived lipopolysaccharide (LPS), as well as LPS-responded soluble CD14, were not only positively correlated with levels of above proinflammation mediators but also the total MOAS score and subscore for aggression against objects or others.Conclusion: Our results collectively demonstrate the presence of leaky gut and further correlate BT-derived LPS and soluble CD14 to onset or severity of aggression possibly by driving proinflammation response in inpatients with ScZ, which indicates that BT may be a novel anti-inflammation therapeutic target for aggression prophylaxis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|