Blockade of the renin-angiotensin system with delphinidin, cyanin, and quercetin
| Autor: | Warisara Parichatikanond, Darawan Pinthong, Supachoke Mangmool |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class media_common.quotation_subject Pharmaceutical Science Angiotensin-Converting Enzyme Inhibitors Blood Pressure Analytical Chemistry Anthocyanins Renin-Angiotensin System chemistry.chemical_compound Glucosides Internal medicine Drug Discovery Renin–angiotensin system Renin medicine Humans heterocyclic compounds Internalization Antihypertensive Agents media_common Pharmacology biology Chemistry Organic Chemistry food and beverages Angiotensin-converting enzyme Receptor antagonist Angiotensin II Endocrinology HEK293 Cells Complementary and alternative medicine Hypertension biology.protein Molecular Medicine Quercetin Signal transduction Delphinidin Signal Transduction |
| Zdroj: | Planta medica. 78(15) |
| ISSN: | 1439-0221 |
| Popis: | Overactivation of the renin-angiotensin system is one of the most important risk factors for the development of hypertension. The use of the crude extracts and/or active compounds, such as anthocyanins and quercetin, of herbal plants that have antihypertensive effects is beneficial for decreasing of blood pressure level. However, the molecular mechanisms by which anthocyanins (delphinidin and cyanin) and quercetin regulate the renin-angiotensin system are not completely understood. In this study, we demonstrate that delphinidin, cyanin, and quercetin interrupt the renin-angiotensin system signaling pathway by inhibiting the angiotensin-converting enzyme activity and decreasing its mRNA production. Furthermore, treatment with either delphinidin or cyanin significantly inhibited renin mRNA production. However, delphinidin, cyanin, and quercetin did not act as the angiotensin II type 1 receptor antagonist and did not play roles in the regulation of its internalization. The direct inhibition of components of the renin-angiotensin system advances our understanding of the antihypertensive effects of these compounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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