Association Between Diabetes and COVID-19: A Retrospective Observational Study With a Large Sample of 1,880 Cases in Leishenshan Hospital, Wuhan

Autor: Meilin Yi, Zeming Liu, Rongfen Gao, Jinpeng Li, Yibin Yang, Xiaohui Wu, Yihui Huang, Kuan Luo, Jincao Chen, Guang Zeng, Tingbao Zhang, Jianglong Huang, Liang Guo
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Male
0301 basic medicine
China
Multivariate statistics
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Endocrinology
Diabetes and Metabolism
Pneumonia
Viral
030209 endocrinology & metabolism
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Diabetes Complications
Betacoronavirus
03 medical and health sciences
0302 clinical medicine
Endocrinology
Risk Factors
Diabetes mellitus
Internal medicine
medicine
Humans
Pandemics
Retrospective Studies
Original Research
lcsh:RC648-665
SARS-CoV-2
Proportional hazards model
business.industry
Mortality rate
Univariate
clinical courses
COVID-19
Retrospective cohort study
Middle Aged
medicine.disease
Comorbidity
comorbidity
030104 developmental biology
diabetes mellitus
Female
prognosis
Coronavirus Infections
business
Follow-Up Studies
Zdroj: Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 11 (2020)
ISSN: 1664-2392
Popis: Aims: This study aimed to investigate the clinical courses and outcomes of diabetes mellitus patients with coronavirus disease 2019 (COVID-19) in Wuhan. Methods: This study enrolled 1,880 consecutive patients with confirmed COVID-19 in Leishenshan Hospital. We collected and analyzed their data, including demographic data, history of comorbidity, clinical symptoms, laboratory tests, chest computed tomography (CT) images, treatment options, and survival. Results: The percentages of patients with diabetes among the severe and critical COVID-19 cases were higher than those among the mild or general cases (89.2%, 10.8 vs. 0%, p = 0.001). However, patients with and without diabetes showed no difference in the follow-up period (p = 0.993). The mortality rate in patients with or without diabetes was 2.9% (n = 4) and 1.1% (n = 9), respectively (p = 0.114). Univariate and multivariate Cox regression analyses and the Kaplan-Meier curves did not show any statistically significant differences between patients with and without diabetes (all p > 0.05). Conclusions: Our study results suggested that diabetes had no effect on the prognosis of COVID-19 patients but had a negative association with their clinical courses. These results may be useful for clinicians in the management of diabetic patients with COVID-19.
Databáze: OpenAIRE
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