Association Between Diabetes and COVID-19: A Retrospective Observational Study With a Large Sample of 1,880 Cases in Leishenshan Hospital, Wuhan
Autor: | Meilin Yi, Zeming Liu, Rongfen Gao, Jinpeng Li, Yibin Yang, Xiaohui Wu, Yihui Huang, Kuan Luo, Jincao Chen, Guang Zeng, Tingbao Zhang, Jianglong Huang, Liang Guo |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Adult
Male 0301 basic medicine China Multivariate statistics medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Endocrinology Diabetes and Metabolism Pneumonia Viral 030209 endocrinology & metabolism lcsh:Diseases of the endocrine glands. Clinical endocrinology Diabetes Complications Betacoronavirus 03 medical and health sciences 0302 clinical medicine Endocrinology Risk Factors Diabetes mellitus Internal medicine medicine Humans Pandemics Retrospective Studies Original Research lcsh:RC648-665 SARS-CoV-2 Proportional hazards model business.industry Mortality rate Univariate clinical courses COVID-19 Retrospective cohort study Middle Aged medicine.disease Comorbidity comorbidity 030104 developmental biology diabetes mellitus Female prognosis Coronavirus Infections business Follow-Up Studies |
Zdroj: | Frontiers in Endocrinology Frontiers in Endocrinology, Vol 11 (2020) |
ISSN: | 1664-2392 |
Popis: | Aims: This study aimed to investigate the clinical courses and outcomes of diabetes mellitus patients with coronavirus disease 2019 (COVID-19) in Wuhan. Methods: This study enrolled 1,880 consecutive patients with confirmed COVID-19 in Leishenshan Hospital. We collected and analyzed their data, including demographic data, history of comorbidity, clinical symptoms, laboratory tests, chest computed tomography (CT) images, treatment options, and survival. Results: The percentages of patients with diabetes among the severe and critical COVID-19 cases were higher than those among the mild or general cases (89.2%, 10.8 vs. 0%, p = 0.001). However, patients with and without diabetes showed no difference in the follow-up period (p = 0.993). The mortality rate in patients with or without diabetes was 2.9% (n = 4) and 1.1% (n = 9), respectively (p = 0.114). Univariate and multivariate Cox regression analyses and the Kaplan-Meier curves did not show any statistically significant differences between patients with and without diabetes (all p > 0.05). Conclusions: Our study results suggested that diabetes had no effect on the prognosis of COVID-19 patients but had a negative association with their clinical courses. These results may be useful for clinicians in the management of diabetic patients with COVID-19. |
Databáze: | OpenAIRE |
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