Endocrine Regulation of Bone and Energy Metabolism in Hibernating Mammals
| Autor: | Gregory L. Florant, Seth W. Donahue, Alison H. Doherty |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Mammals
Hibernation medicine.medical_specialty Energy metabolism Plant Science Biology Bone and Bones Hormones Cell biology Bone remodeling Endocrinology Internal medicine medicine Animals Endocrine system Calcium Animal Science and Zoology Bone formation Hormone metabolism Energy Metabolism Homeostasis Theme and Variations: Heterothermy in Mammals Hormone |
| Zdroj: | Integrative and Comparative Biology. 54:463-483 |
| ISSN: | 1557-7023 1540-7063 |
| DOI: | 10.1093/icb/icu001 |
| Popis: | Precise coordination among organs is required to maintain homeostasis throughout hibernation. This is particularly true in balancing bone remodeling processes (bone formation and resorption) in hibernators experiencing nutritional deprivation and extreme physical inactivity, two factors normally leading to pronounced bone loss in non-hibernating mammals. In recent years, important relationships between bone, fat, reproductive, and brain tissues have come to light. These systems share interconnected regulatory mechanisms of energy metabolism that potentially protect the skeleton during hibernation. This review focuses on the endocrine and neuroendocrine regulation of bone/fat/energy metabolism in hibernators. Hibernators appear to have unique mechanisms that protect musculoskeletal tissues while catabolizing their abundant stores of fat. Furthermore, the bone remodeling processes that normally cause disuse-induced bone loss in non-hibernators are compared to bone remodeling processes in hibernators, and possible adaptations of the bone signaling pathways that protect the skeleton during hibernation are discussed. Understanding the biological mechanisms that allow hibernators to survive the prolonged disuse and fasting associated with extreme environmental challenges will provide critical information regarding the limit of convergence in mammalian systems and of skeletal plasticity, and may contribute valuable insight into the etiology and treatment of human diseases. |
| Databáze: | OpenAIRE |
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