| Autor: |
Diana L., Regazzoni R., Sozzi M., Piconi S., Borghesi L., Lazzaroni E., Basilico P., Aliprandi A., Bolognini N., Bonardi D. R., Colombo D., Salmaggi A. |
| Přispěvatelé: |
Diana, L, Regazzoni, R, Sozzi, M, Piconi, S, Borghesi, L, Lazzaroni, E, Basilico, P, Aliprandi, A, Bolognini, N, Bonardi, D, Colombo, D, Salmaggi, A |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of the neurological sciences. 444 |
| ISSN: |
1878-5883 |
| Popis: |
Background: SARS-COV-2 infection has been associated to long-lasting neuropsychiatric sequelae, including cognitive deficits, that persist after one year. However, longitudinal monitoring has been scarcely performed. Here, in a sample of COVID-19 patients, we monitor cognitive, psychological and quality of life-related profiles up to 22 months from resolution of respiratory disease. Methods: Out of 657 COVID-19 patients screened at Manzoni Hospital (Lecco, Italy), 22 underwent neuropsychological testing because of subjective cognitive disturbances at 6 months, 16 months, and 22 months. Tests of memory, attention, and executive functions were administered, along with questionnaires for depressive and Post-traumatic stress disorder (PTSD) symptoms, psychological well-being and quality of life. Cross-sectional descriptives, correlational, as well as longitudinal analyses considering COVID19-severity were carried out. A preliminary comparison with a sample of obstructive sleep apneas patients was also performed. Results: Around 50% of COVID-19 patients presented with cognitive deficits at t0. The most affected domain was verbal memory. Pathological scores diminished over time, but a high rate of borderline scores was still observable. Longitudinal analyses highlighted improvements in verbal and non-verbal long term memory, as well as attention, and executive functioning. Depression and PTSD-related symptoms were present in 30% of patients. The latter decreased over time and were associated to attentional-executive performance. Conclusions: Cognitive dysfunctions in COVID-19 patients may extend over 1 year, yet showing a significant recovery in several cases. Cognitive alterations are accompanied by a significant psychological distress. Many patients displaying borderline scores, especially those at higher risk of dementia, deserve clinical monitoring. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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