Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease
| Autor: | Uwe Konietzko, Johannes Streffer, Alessia Maddalena, M. Axel Wollmer, Jay Tracy, Britta Müller-Tillmanns, Eva Moritz, Roger M. Nitsch, Daniel Umbricht, Andri Signorell, Esmeralda Garcia, Dominique J.-F. de Quervain, Katharina Henke, Andreas Papassotiropoulos, Marc Hofmann, Christoph Hock, Ulrike Lemke |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Wechsler Memory Scale medicine.medical_specialty Patient Dropouts Neuroscience(all) Mice Transgenic Plaque Amyloid Disease Neuropsychological Tests Hippocampus Antibodies Mice Cognition Alzheimer Disease Predictive Value of Tests Internal medicine mental disorders Activities of Daily Living medicine Dementia Animals Humans Cognitive decline Psychiatry Aged Aged 80 and over Mini–Mental State Examination Amyloid beta-Peptides medicine.diagnostic_test General Neuroscience Meningoencephalitis Immunotherapy Active Middle Aged medicine.disease Peptide Fragments Treatment Outcome Immunization Disease Progression Female Psychology Cognition Disorders |
| Zdroj: | Neuron. 38(4) |
| ISSN: | 0896-6273 |
| Popis: | To test whether antibodies against beta-amyloid are effective in slowing progression of Alzheimer's disease, we assessed cognitive functions in 30 patients who received a prime and a booster immunization of aggregated Abeta(42) over a 1 year period in a placebo-controlled, randomized trial. Twenty patients generated antibodies against beta-amyloid, as determined by tissue amyloid plaque immunoreactivity assay. Patients who generated such antibodies showed significantly slower rates of decline of cognitive functions and activities of daily living, as indicated by the Mini Mental State Examination, the Disability Assessment for Dementia, and the Visual Paired Associates Test of delayed recall from the Wechsler Memory Scale, as compared to patients without such antibodies. These beneficial clinical effects were also present in two of three patients who had experienced transient episodes of immunization-related aseptic meningoencephalitis. Our results establish that antibodies against beta-amyloid plaques can slow cognitive decline in patients with Alzheimer's disease. |
| Databáze: | OpenAIRE |
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