NGAL (Lcn2) monomer is associated with tubulointerstitial damage in chronic kidney disease
| Autor: | Kiyoshi Mori, Thomas L. Nickolas, Mélanie Viltard, Landino Allegri, Maria Luisa Carnevali, David Sola-Del Valle, Paul Tempst, Silvia Mattei, Meghan E. Sise, Hediye Erdjument-Bromage, Michael J. Bennett, Catherine S. Forster, Prasad Devarajan, Jonathan Barasch, Shlomo Kupferman, Nicholas Barasch, Charles Buchen, Achiropita Bovino, Lucia Argentiero, Andrea Magnano |
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| Rok vydání: | 2012 |
| Předmět: |
Pathology
medicine.medical_specialty Urinalysis Urinary system 030232 urology & nephrology Renal function Lipocalin 03 medical and health sciences 0302 clinical medicine Biopsy Medicine 030304 developmental biology 0303 health sciences Kidney Proteinuria medicine.diagnostic_test business.industry Biomarker medicine.disease 3. Good health medicine.anatomical_structure Nephrology pathology medicine.symptom business chronic kidney disease Kidney disease |
| Zdroj: | Kidney International. 82:718-722 |
| ISSN: | 0085-2538 |
| Popis: | The type and the extent of tissue damage inform the prognosis of chronic kidney disease (CKD), but kidney biopsy is not a routine test. Urinary tests that correlate with specific histological findings might serve as surrogates for the kidney biopsy. We used immunoblots and ARCHITECT-NGAL assays to define the immunoreactivity of urinary neutrophil gelatinase–associated lipocalin (NGAL) in CKD, and we used mass spectroscopy to identify associated proteins. We analyzed kidney biopsies to determine whether specific pathological characteristics associated with the monomeric NGAL species. Advanced CKD urine contained the NGAL monomer as well as novel complexes of NGAL. When these species were separated, we found a significant correlation between the NGAL monomer and glomerular filtration rate (r=-0.53, P |
| Databáze: | OpenAIRE |
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