Hepatic osteodystrophy: the influence of liver disease and portal hypertension on cytokine activation
| Autor: | S. W. van der Merwe, D. Attfield, J. Fevery, J. B. van den Bogaerde |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Osteomalacia medicine.diagnostic_test Bone disease Vascular disease business.industry Liver Diseases General Medicine medicine.disease Chronic liver disease Pathogenesis Liver disease Endocrinology Internal medicine Hypertension Portal medicine Cytokines Humans Portal hypertension Liver function tests business |
| Zdroj: | Medical Hypotheses. 54:842-845 |
| ISSN: | 0306-9877 |
| Popis: | Chronic liver disease is frequently complicated by bone disease. The mechanisms leading to bone-loss are unknown but are probably not related to abnormal vitamin D metabolism. The effects of portal hypertension and porto-systemic shunting on bone-loss have not been studied. It is postulated that liver disease, or the complications of liver disease (portal hypertension or porto-systemic shunting), might be responsible for the activation of cytokines. It is further postulated that these cytokines might be the final common pathway leading to bone-loss in both parenchymal and cholestatic liver disorders by modifying osteoblast or osteoclast function. |
| Databáze: | OpenAIRE |
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