One Hundred Ten Years of Allergen Immunotherapy: A Broad Look Into the Future
| Autor: | Peter S. Creticos, Jörg Kleine-Tebbe, Oscar Palomares, Stefan Schülke, Giorgio Walter Canonica, Oliver Pfaar |
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| Rok vydání: | 2020 |
| Předmět: |
Ragweed
Allergen immunotherapy medicine.medical_specialty law.invention 03 medical and health sciences 0302 clinical medicine Clinical report Randomized controlled trial law Immune Tolerance Immunology and Allergy Medicine Humans 030212 general & internal medicine Intensive care medicine House dust mite biology business.industry Atopic dermatitis Allergens medicine.disease biology.organism_classification Rhinitis Allergic Asthma Tolerance induction 030228 respiratory system Tolerability Desensitization Immunologic business |
| Zdroj: | The journal of allergy and clinical immunology. In practice. 9(5) |
| ISSN: | 2213-2201 |
| Popis: | Allergen immunotherapy (AIT) is the only disease-modifying treatment option for patients with type 1–mediated allergic diseases such as allergic rhinitis/rhinoconjunctivitis with/without allergic asthma. Although many innovations have been developed since the first clinical report of Noon et al in 1911, the improvement of clinical efficacy and tolerability of this treatment is still an important unmet need. Hence, much progress has been made in the characterization of the cell types, cytokines, and intracellular signaling events involved in the development, maintenance, and regulation of allergic reactions, and also in the understanding of the mechanisms of tolerance induction in AIT. This comprehensive review aims to summarize the current innovative approaches in AIT, but also gives an outlook on promising candidates of the future. On the basis of an extensive literature review, integrating a clinical point of view, this article focuses on recent and future innovations regarding biologicals, allergen-derived peptides, recombinant allergens, “Toll”-like receptor agonists and other adjuvants, and novel application routes being developed for future AIT. |
| Databáze: | OpenAIRE |
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