In Vivo and In Vitro Cartilage Differentiation from Embryonic Epicardial Progenitor Cells
| Autor: | Paul Palmquist-Gomes, Ernesto Marín-Sedeño, Adrián Ruiz-Villalba, Gustavo Adolfo Rico-Llanos, José María Pérez-Pomares, Juan Antonio Guadix |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Organic Chemistry
cardiac regeneration chondrocytes Cell Differentiation General Medicine differentiation Catalysis Computer Science Applications Inorganic Chemistry Chondrocytes Neural Crest proepicardium epicardium Physical and Theoretical Chemistry avian embryo cartilage epicardial-derived cells Molecular Biology Pericardium Spectroscopy quail to chick chimeras Embryonic Stem Cells |
| Zdroj: | International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3614 |
| Popis: | The presence of cartilage tissue in the embryonic and adult hearts of different vertebrate species is a well-recorded fact. However, while the embryonic neural crest has been historically considered as the main source of cardiac cartilage, recently reported results on the wide connective potential of epicardial lineage cells suggest they could also differentiate into chondrocytes. In this work, we describe the formation of cardiac cartilage clusters from proepicardial cells, both in vivo and in vitro. Our findings report, for the first time, cartilage formation from epicardial progenitor cells, and strongly support the concept of proepicardial cells as multipotent connective progenitors. These results are relevant to our understanding of cardiac cell complexity and the responses of cardiac connective tissues to pathologic stimuli. |
| Databáze: | OpenAIRE |
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