Presence of lymphocyte aggregates in the synovium of patients with early arthritis in relationship to diagnosis and outcome: is it a constant feature over time?
| Autor: | Maria J H Boumans, Rogier M. Thurlings, Paul P. Tak, Marleen G H van de Sande, Danielle M. Gerlag, Carla A. Wijbrandts, Maria Grazia Modesti |
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| Přispěvatelé: | Clinical Immunology and Rheumatology, AII - Amsterdam institute for Infection and Immunity |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Immunology Arthritis Severity of Illness Index General Biochemistry Genetics and Molecular Biology Arthritis Rheumatoid Diagnosis Differential Arthroscopy Rheumatology Synovitis Internal medicine Immunology and Allergy Medicine Humans Lymphocytes Prospective cohort study Aged Cell Aggregation business.industry Synovial Membrane Middle Aged medicine.disease Prognosis Connective tissue disease Cell aggregation medicine.anatomical_structure Rheumatoid arthritis Female Synovial membrane business Follow-Up Studies |
| Zdroj: | Annals of the rheumatic diseases, 70(4), 700-703. BMJ Publishing Group |
| ISSN: | 1468-2060 0003-4967 |
| Popis: | ObjectivesTo evaluate the presence of lymphocyte aggregates in synovial tissue of patients with early arthritis in relationship to clinical outcome and to determine whether this is a stable feature over time.MethodsArthroscopic synovial biopsy samples were collected in a prospective cohort of disease-modifying antirheumatic drug-naïve patients with early arthritis (ResultsLN was present in 36% of all patients and FDCs in 15% of patients with LN. Presence of lymphocyte aggregates differed over time. LN was associated with the degree of synovial inflammation. There was no relationship between the presence of lymphocyte aggregates at baseline and definitive diagnosis or clinical outcome after follow-up.ConclusionsPresence of lymphocyte aggregates is a dynamic phenomenon related to the degree of synovitis and can be detected in different forms of early arthritis. This feature does not appear to be related to clinical outcome. |
| Databáze: | OpenAIRE |
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