Bioactive glass based scaffolds coated with gelatin for the sustained release of icariin
| Autor: | Katharina Schuhladen, Aldo R. Boccaccini, Theresa Reiter, Jasmin Hum, Tanja Panick, Judith A. Roether |
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| Rok vydání: | 2019 |
| Předmět: |
food.ingredient
Simulated body fluid 0206 medical engineering Biomedical Engineering 02 engineering and technology engineering.material Gelatin Article law.invention Scaffold Biomaterials chemistry.chemical_compound food Coating law lcsh:TA401-492 medicine Bioactive glass lcsh:QH301-705.5 Drug release 021001 nanoscience & nanotechnology 020601 biomedical engineering Icariin medicine.anatomical_structure Compressive strength lcsh:Biology (General) chemistry Chemical engineering Drug delivery engineering lcsh:Materials of engineering and construction. Mechanics of materials Cortical bone 0210 nano-technology Biotechnology |
| Zdroj: | Bioactive Materials Bioactive Materials, Vol 4, Iss, Pp 1-7 (2019) |
| ISSN: | 2452-199X |
| DOI: | 10.1016/j.bioactmat.2018.10.001 |
| Popis: | Gelatin-coated, 3D sponge-like scaffolds based on 45S5 bioactive glass were produced using the foam replication technique. Compressive strength tests of gelatin-coated samples compared to uncoated scaffolds showed significant strengthening and toughening effects of the gelatin coating with compressive strength values in the range of cortical bone. Additionally, the crosslinked gelatin network (using either caffeic acid or N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC)/N-hxdroxysuccinimide (NHS) as crosslinking agent) was shown to be a suitable candidate for the sustained release of the bioactive molecule icariin. Concerning bioactivity of the produced scaffolds, characterization by FTIR and SEM indicated the formation of hydroxyapatite (HA) in all samples after immersion in simulated body fluid (SBF) for 14 days, highlighting the favorable combination of mechanical robustness, bioactivity and drug delivery capability of this new type of scaffolds. Graphical abstract Image 1 Highlights • Foam like bioactive glass scaffolds produced by replication technique. • Gelatin coatings confer increased compression strength to scaffolds. • Crosslinked gelatin coating is suitable candidate for the sustained release of icariin. • Favorable combination of bioactivity, gelatin coating and icariin release demonstrated. |
| Databáze: | OpenAIRE |
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