Molecular testing in fine‐needle aspiration of thyroid nodules

Autor:	Valarie McMurtry, Sule Canberk, Georgios Deftereos
Rok vydání:	2022
Předmět:	Histology General Medicine Pathology and Forensic Medicine
Zdroj:	Diagnostic Cytopathology. 51:36-50
ISSN:	1097-0339 8755-1039
DOI:	10.1002/dc.25035
Popis:	Thyroid nodules are commonly faced by clinicians as palpable nodules or incidentally identified on imaging. Nodules that are found to be suspicious by imaging can be biopsied by fine needle aspiration, which can yield material for molecular testing to refine the diagnosis.The current literature concerning molecular testing in thyroid nodules including available commercial assays was reviewed and summarized.Commonly encountered alterations include mutations in RAS, BRAF, TERT promoter, PTEN, and DICER1 as well as fusions of RET, ALK, PAX8-PPARγ, and NTRK. This article provides a summary of these molecular alterations, commercially available molecular assays, and general considerations for thyroid epithelial malignancies and benign thyroid nodules.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cdd1ef09840f60b86a94d1c8a7ee35d https://doi.org/10.1002/dc.25035 Zobrazit plný text záznamu Plný text