DNA ploidy patterns in gastric adenocarcinoma
| Autor: | Hye Jae Cho, Jung Young Kim |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Pathology medicine.medical_specialty Proliferative index Aneuploidy Adenocarcinoma Biology Stomach Neoplasms medicine Gastric mucosa Humans Aged Signet ring cell Stomach Cancer Cell Differentiation General Medicine Middle Aged Flow Cytometry medicine.disease Ki-67 Antigen medicine.anatomical_structure Gastric Mucosa Female Field cancerization Cell Division Research Article |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| DOI: | 10.3346/jkms.2000.15.2.159 |
| Popis: | To assess the value of DNA ploidy, flow cytometric analysis was performed on unfixed fresh materials obtained from 86 patients with gastric cancer who underwent stomach resection. We evaluated the DNA content of gastric carcinoma cells from four different sites and compared it with Ki-67 proliferating activity, and other pathologic parameters. The incidence of aneuploid and diploid was similar (48.8% vs. 51.1%). Early gastric carcinoma showed a higher rate of the diploid pattern (75%) compared to that of advanced gastric carcinoma (47.3%). DNA diploidy was noted increasingly in diffuse-type tumors according to Lauren, in signet ring cell type tumor according to WHO classification and in poorly differentiated tumors (p |
| Databáze: | OpenAIRE |
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