Effect of Imipramine and Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Activity of Proline-Specific Peptidases in the Brain of Rats with Experimental Anxious-Depressive Syndrome
| Autor: | N. A. Krupina, G. N. Kryzhanovskii, N. N. Zolotov, E. Yu. Kushnareva, N. N. Khlebnikova |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Imipramine endocrine system medicine.medical_specialty Pyrrolidines Dipeptidyl Peptidase 4 Serotonin reuptake inhibitor Striatum Antidepressive Agents Tricyclic Anxiety Nucleus accumbens General Biochemistry Genetics and Molecular Biology Dipeptidyl peptidase Methionine Prolyl endopeptidase Internal medicine medicine Animals Protease Inhibitors Rats Wistar Swimming Depressive Disorder Chemistry Serine Endopeptidases digestive oral and skin physiology Brain General Medicine Rats Endocrinology Animals Newborn nervous system Biochemistry Hypothalamus Prolyl Oligopeptidases medicine.drug Behavioural despair test |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 152:409-412 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Activities of prolyl endopeptidase and dipeptidyl peptidase IV in the frontal cortex, hypothalamus, nucleus accumbens, striatum, and hippocampus were measured in rats with the experimental anxious-depressive syndrome induced by treatment with a dipeptidyl peptidase IV inhibitor during the early postnatal period (days 5-18). Prolyl endopeptidase activity was elevated in the frontal cortex, hypothalamus, and nucleus accumbens. Increased activity of dipeptidyl peptidase IV was observed in the hypothalamus and striatum. Norepinephrine/serotonin reuptake inhibitor, imipramine, and noncompetitive prolyl endopeptidase inhibitor, benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine, were shown to abolish depression-like behavior of animals in the forced swimming test. These compounds had a normalizing effect on activities of prolyl endopeptidase and dipeptidyl peptidase IV in brain structures of rats. |
| Databáze: | OpenAIRE |
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