Aberrant expression for microRNA is potential crucial factors of haemorrhoid
| Autor: | Haikun Zhou, Chunsheng Luo, Hong Lu, Chen Wang, Wei Yang, Chengkun Song, Yaojie Xin, Te Liu, Qingming Wang, Yunhua Peng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
lcsh:QH426-470 Signal transduction pathways RNA-Seq Biology Hemorrhoids 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation microRNA Genetics Humans Epigenetics KEGG Gene 030304 developmental biology Haemorrhoids 0303 health sciences Gene Expression Profiling Research Computational Biology High-Throughput Nucleotide Sequencing Molecular Sequence Annotation General Medicine Middle Aged Synaptic vesicle cycle Immunohistochemistry MicroRNAs lcsh:Genetics Gene Ontology Gene Expression Regulation Cancer research Disease Susceptibility Signal transduction 030217 neurology & neurosurgery Biomarkers Signal Transduction |
| Zdroj: | Hereditas, Vol 157, Iss 1, Pp 1-12 (2020) Hereditas |
| ISSN: | 1601-5223 |
| DOI: | 10.1186/s41065-020-00139-9 |
| Popis: | Background Haemorrhoids occur commonly and frequently in the human digestive system. There are diverse causes of haemorrhoids and their in-depth pathogenesis is still currently unclear. Methods In this study, we explored haemorrhoids from an epigenetics perspective by employing RNA-Seq for comprehensive and in-depth analysis of the differences in microRNA (miRNA) transcripts between haemorrhoidal tissue and normal tissue in 48 patients with Grade II and above haemorrhoids. Results The results showed that 9 miRNAs were significantly upregulated (ratio > 3.5 and P-value 0.6 and P-value |
| Databáze: | OpenAIRE |
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