Effect of age and estrogen on biochemical markers of bone turnover in postmenopausal women: a population-based study from Nepal
| Autor: | Sumitra Ghimire, Bashu Dev Pardhe, Sabala Pathak, Puspa Raj Khanal, Anjeela Bhetwal, Shreena Shakya, Sujan Babu Marahatta |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Bone disease medicine.drug_class Osteoporosis International Journal of Women's Health Bone tissue Bone remodeling bone markers Nepal Internal medicine estradiol Maternity and Midwifery medicine Original Research business.industry Mortality rate Obstetrics and Gynecology medicine.disease osteoporosis Menopause postmenopause medicine.anatomical_structure Endocrinology Oncology Estrogen business Body mass index |
| Zdroj: | International Journal of Women's Health |
| ISSN: | 1179-1411 |
| Popis: | Bashu Dev Pardhe, Sabala Pathak, Anjeela Bhetwal, Sumitra Ghimire, Shreena Shakya, Puspa Raj Khanal, Sujan Babu Marahatta Department of Laboratory Medicine, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal Background: Osteoporosis, a common disease worldwide, is characterized by low bone mass and architectural deterioration of bone tissue, leading to enhanced bone fragility and increase in fracture risks. Both menopause and aging are related factors leading to greater risk of bone disease, particularly among postmenopausal women. Hence, the main purpose of this study was to investigate the differences in biochemical markers of bone turnover and to evaluate the association of hormones and age-related factors with biochemical markers between pre- and postmenopausal women.Methods: A descriptive cross-sectional study was conducted over a period of 6 months among the female population of Dholahity community, Lalitpur, Nepal. A total of 496 healthy women were selected based on the questionnaire strategy. Among them, 244 were premenopausal and 252 were postmenopausal women. Different bone markers were evaluated as per the guideline provided by the reagent manufacturer, and hormonal assay, particularly estradiol level assessment, was performed by chemiluminescence immunoassay-based technique.Results: A significant decrease in serum calcium level and estradiol level was observed in postmenopausal women as compared to premenopausal women, whereas a significant increase in serum phosphorus and alkaline phosphatase (ALP) levels was seen among postmenopausal (p |
| Databáze: | OpenAIRE |
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