Characterization of laser speckle flowgraphy pulse waveform parameters for the evaluation of the optic nerve head and retinal circulation

Autor:	Ayako Anraku, Takashi Sato, Koji Nitta, Toru Nakazawa, Nobuyuki Shoji, Goji Tomita, Makoto Araie, Kazuhisa Sugiyama, Aiko Iwase, Nobuko Enomoto, Tomoaki Shiba
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Adult Male 0301 basic medicine Intraocular pressure Central retinal artery medicine.medical_specialty Science Optic Disk Pulse Wave Analysis Retina Article 03 medical and health sciences chemistry.chemical_compound Medical research 0302 clinical medicine Atrophy medicine.artery Ophthalmology Heart rate Laser-Doppler Flowmetry medicine Humans Waveform Prospective Studies Intraocular Pressure Aged Aged 80 and over Multidisciplinary business.industry Microcirculation Retinal Blood flow Middle Aged medicine.disease Cross-Sectional Studies 030104 developmental biology Blood pressure chemistry Regional Blood Flow 030221 ophthalmology & optometry Optic nerve Medicine Female business Blood Flow Velocity
Zdroj:	Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) Scientific Reports
ISSN:	2045-2322
Popis:	To characterize laser speckle flowgraphy (LSFG) pulse waveform parameters for ocular circulation evaluation, a multicenter, prospective, cross-sectional study was conducted in 111 eyes of 86 healthy Japanese individuals. Optic nerve head (ONH) tissue-area, vessel-area mean blur rate (MT and MV, respectively), and MT and MV pulse waveform parameters were obtained using LSFG and ONH structural parameters using planimetry. Multivariate linear mixed-effects modeled regression analysis identified factors contributing to MT- or MV-waveforms using age, gender, smoking history, body mass index, systolic and diastolic blood pressure, heart rate, intraocular pressure, axial length, disc, rim, and β-peripapillary atrophy areas, MT or MV, central retinal artery, and vein equivalents (CRAE and CRVE) as explanatory variables. MT- and MV-waveforms significantly correlated with one or more systemic factors, consistent with previous studies. Following confounding factor adjustment, MT-Skew significantly negatively correlated with β-PPA area (P = 0.026); MT- and MV-flow acceleration index positively correlated with CRAE, MT, and MV (P = 0.041–
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cd81344d96ef08dbdff534bd13bfce3 https://doaj.org/article/0de60f9cb2d04a4091b46b2b7ed93a59 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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