Definition of nocturnal gastroesophageal reflux for studies on respiratory diseases
| Autor: | Sören Berg, Leif Nordang, Thorarinn Gislason, Bryndis Benediktsdottir, Christer Janson, Einar Bjornsson, Elizabeth Cook, Sunna Guðlaugsdóttir, Anna Soffía Guðmundsdóttir, S Juliusson, Össur Ingi Emilsson, Isleifur Olafsson |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Esophageal pH Monitoring Respiratory Tract Diseases Population Iceland Disease Nocturnal Gastroenterology 03 medical and health sciences Laryngopharyngeal reflux 0302 clinical medicine Surveys and Questionnaires Internal medicine medicine Humans Exhaled breath condensate Respiratory system education Asthma education.field_of_study Laryngoscopy business.industry Incidence Reflux Hydrogen-Ion Concentration Middle Aged medicine.disease Breath Tests Population Surveillance 030220 oncology & carcinogenesis Gastroesophageal Reflux Female 030211 gastroenterology & hepatology business Follow-Up Studies |
| Zdroj: | Scandinavian Journal of Gastroenterology. 51:524-530 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.3109/00365521.2015.1124284 |
| Popis: | Nocturnal gastroesophageal reflux (nGER) has been associated with respiratory diseases. Our aim was to study a questionnaire method to identify nGER subjects with respiratory involvement in a general population.A subgroup of Icelandic participants in the European Community Respiratory Health Survey III (ECRHS III) reporting symptoms of nGER (n = 48) as well as age and gender paired controls (n = 42) were studied further by a structured interview, questionnaires, laryngeal fibrescopy, and exhaled breath condensate. A subgroup underwent 24-h oesophageal pH impedance (24-h MII-pH) measurements. Symptoms of nGER were assessed with a modified version of the reflux disease questionnaire (RDQ), where symptoms were divided into daytime and nocturnal. A report of nGER both at baseline and at follow-up was defined as persistent nGER.Participants reporting persistent nGER had significantly more signs of laryngopharyngeal reflux according to the reflux finding score than those without nGER (Mean ± SD: 5.1 ± 2.3 vs. 3.9 ± 2.2, p = 0.02). Of the 16 persistent nGER subjects that underwent 24-h MII-pH, 11 had abnormal gastroesophageal reflux, but none of three control subjects (69% vs. 0%). Pepsin was more commonly found in exhaled breath condensate in the nGER group (67% vs. 45%, p = 0.04).Participants with nGER symptoms at least once a month, reported on two occasions, had a high level of positive 24-h MII-pH measurements, laryngeal inflammation and pepsin in exhaled breath condensate. This nGER definition identified a representable group for studies on nGER and respiratory diseases in a general population. |
| Databáze: | OpenAIRE |
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