Halothane Attenuates Small Arteriole Vasodilation to Serotonin (5-HT) in Skeletal Muscle
| Autor: | Ping Y. Zhang, Patrick D. Harris, Eleanor F. Asher, Nancy L. Alsip |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Methysergide Vasodilation Nitric Oxide Microcirculation Arteriole medicine.artery Internal medicine medicine Animals Ergolines 5-HT receptor Dose-Response Relationship Drug business.industry Muscles Rats Inbred Strains Rats Arterioles Anesthesiology and Pain Medicine Endocrinology Anesthesia Cremaster muscle Halothane business medicine.drug |
| Zdroj: | Anesthesia & Analgesia. 73:583 |
| ISSN: | 0003-2999 |
| Popis: | Inhaled anesthetics may have an effect on the microcirculation through selective alteration of receptor-mediated control. Halothane was chosen because its actions in the microcirculation have been determined previously. Serotonin has received recent attention as a potential mediator of vascular changes in a number of disease states. We obtained concentration-response curves for serotonin-induced constriction of large arterioles and dilation of small arterioles (less than 60 microns diameter) in the cremaster muscle of halothane-anesthetized and decerebrate rats. Cremaster muscles were prepared for microscopic viewing, leaving the neural and vascular supply intact. Serotonin concentration-response curves were obtained before and after receptor antagonist application. Large arteriole constriction was not affected by halothane. Dilation of small arterioles was decreased in halothane-anesthetized animals but enhanced in the presence of methysergide, a nonspecific antagonist. These data indicate that halothane interferes with occupancy of 5-hydroxytryptamine receptors. |
| Databáze: | OpenAIRE |
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