Protein-Restricted Diets in Diabetic Nephropathy
| Autor: | William E. Mitch, John A. D'Elia, Donald G. Miller, Bruce R. Bistrian, Susan E. Levine, Sherry Smith-Ossman, Ray E. Gleason |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_specialty business.industry Renal function Glomerulonephritis Middle Aged urologic and male genital diseases medicine.disease Protein-Restricted Diets Diabetic nephropathy Diabetes Mellitus Type 1 Endocrinology Diabetes mellitus Internal medicine medicine Humans Kidney Failure Chronic Diabetic Nephropathies Female In patient Dietary Proteins Restricted diet business |
| Zdroj: | Europe PubMed Central |
| ISSN: | 2235-3186 1660-8151 |
| DOI: | 10.1159/000185582 |
| Popis: | Low-protein diets in nondiabetic renal failure may slow the progressive loss of renal function in some patients, but few studies have detailed the nutritional consequences of these diets in patients with diabetic nephropathy. We studied 7 patients with insulin-dependent diabetes mellitus and chronic renal insufficiency [mean +/- SEM creatinine clearance (S, U): 28.3 +/- 6.5 ml/min (0.47 +/- 0.11 ml/s x 1.73/A)] for 15 weeks who were prescribed a diet of 0.6 g protein/kg ideal body weight. Midarm muscle circumference (24.1 +/- 1.8 at onset vs. 24.5 +/- 1.5 cm at completion), triceps skinfold thickness (21.6 +/- 3.1 vs. 21.0 +/- 1.5 mm), body weight (71.8 +/- 4.1 vs. 71.2 +/- 4.6 kg), and serum albumin [3.0 +/- 0.1 vs. 3.2 +/- 0.1 g/dl (30 +/- 1 vs. 32 +/- 1 g/l)] remained stable. Based on urinary nitrogen excretion, diet diaries overestimated the degree of dietary protein restriction; there was good adherence to the diet as evidenced by a reduction in urinary urea nitrogen (average 32%). Blood glucose control was maintained despite increased carbohydrate intake. On average, creatinine clearance did not change significantly, but proteinuria diminished slightly (1.8 +/- 0.2 vs. 1.5 +/- 0.6 g/day). These results indicate that 0.6 g/kg/day protein diets did not cause protein depletion in insulin-dependent diabetic patients. Longer-term studies are indicated to assess more fully the efficacy of these dietary regimens in reducing proteinuria or benefiting diabetic nephropathy. |
| Databáze: | OpenAIRE |
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