Clinical aspects of cell death in breast cancer: the polyamine pathway as a new target for treatment
| Autor: | Diane E. McCloskey, Nancy E. Davidson, Patrick M. Woster, Hillary A. Hahm, Robert A. Casero |
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| Rok vydání: | 2000 |
| Předmět: |
Cancer Research
Programmed cell death Neoplasms Hormone-Dependent Endocrinology Diabetes and Metabolism Antineoplastic Agents Apoptosis Breast Neoplasms Biology Adenocarcinoma chemistry.chemical_compound Endocrinology Breast cancer Downregulation and upregulation Acetyltransferases medicine Polyamines Tumor Cells Cultured Humans Clinical Trials Phase I as Topic Dose-Response Relationship Drug Cell growth Estrogens medicine.disease Cell biology Neoplasm Proteins Metabolic pathway Polyamine Catabolism Oncology chemistry Cancer research Female Spermine Polyamine Intracellular Cell Division |
| Zdroj: | Endocrine-related cancer. 6(1) |
| ISSN: | 1351-0088 |
| Popis: | Because intracellular polyamines have a critical role in cell proliferation and death pathways, the polyamine metabolic pathway represents a potential target for intervention in cancers. A number of polyamine analogues have been identified that downregulate polyamine synthesis and enhance polyamine catabolism, thereby depleting intracellular polyamines. Treatment of human breast cancer cell lines in culture with these analogues has been shown to decrease cell proliferation and induce programmed cell death. Phase I studies with one analogue are now complete, setting the stage for phase II trials to determine efficacy, in addition to preclinical studies to examine combinations of polyamine analogues and conventional cytotoxics. |
| Databáze: | OpenAIRE |
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