Reduced dorso-lateral prefrontal cortex in treatment resistant schizophrenia
| Autor: | Jair de Jesus Mari, Rodrigo A. Bressan, Andrea Parolin Jackowski, Elisa Brietzke, Idaiane Assunção, João Sato, Ary Gadelha, Vanessa Kiyomi Ota, Deyvis Rocha, Sintia Iole Belangero, André Zugman |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Refractory period Prefrontal Cortex Young Adult Cortex (anatomy) medicine Image Processing Computer-Assisted Humans Cortical surface Prospective cohort study Treatment resistant Biological Psychiatry Anatomy medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health medicine.anatomical_structure Schizophrenia Treatment resistant schizophrenia Female Nerve Net Lateral prefrontal cortex Psychology Neuroscience Antipsychotic Agents |
| Zdroj: | Schizophrenia research. 148(1-3) |
| ISSN: | 1573-2509 |
| Popis: | article i nfo Background: Treatment resistance affects up to one third of patients with schizophrenia (SCZ). A better un- derstanding of its biological underlying processes could improve treatment. The aim of this study was to compare cortical thickness between non-resistant SCZ (NR-SCZ), treatment-resistant SCZ (TR-SCZ) patients and healthy controls (HC). Methodology: Structural MRI scans were obtained from 3 groups of individuals: 61 treatment resistant SCZ in- dividuals, 67 non-resistant SCZ and 80 healthy controls. Images were analyzed using cortical surface model- ling (implemented in freesurfer package) to identify group differences in cortical thickness. Statistical significant differences were identified using Monte-Carlo simulation method with a corrected p-cluster b 0.01. Results: Patients in the TR-SCZ group showed a widespread reduction in cortical thickness in frontal, parietal, temporal and occipital regions bilaterally. NR-SCZ group had reduced cortex in two regions (left superior frontal cortex and left caudal middle frontal cortex). TR-SCZ group also showed decreased thickness in the left dorso- lateral prefrontal cortex (DLPFC) when compared with patients from NR-SCZ group. Conclusions: The reduction in cortical thickness in DLPFC indicates a more severe form of the disease or a specific finding for this group. Alterations in this region should be explored as a putative marker for treatment resis- tance. Prospective studies, with individuals being followed from first episode psychosis until refractoriness is di- agnosed, are needed to clarify these hypotheses. |
| Databáze: | OpenAIRE |
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