Fueling Cell Invasion through Extracellular Matrix
| Autor: | David R. Sherwood, Aastha Garde |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cell invasion
0303 health sciences Proteases Cell Energy metabolism Cancer metastasis Actomyosin Cell Biology Biology Actins Article Extracellular Matrix Cell biology Extracellular matrix 03 medical and health sciences 0302 clinical medicine Immune system medicine.anatomical_structure Cell Movement medicine Glycolysis 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Trends Cell Biol |
| ISSN: | 0962-8924 |
| DOI: | 10.1016/j.tcb.2021.01.006 |
| Popis: | Cell invasion through extracellular matrix (ECM) plays pivotal roles in cell dispersal during development, immune cell trafficking, and cancer metastasis. Many elegant studies have revealed the specialized cellular protrusions, proteases, and distinct modes of migration invasive cells use to overcome ECM barriers. Less clear, however, is how invasive cells provide energy, and specifically ATP, to power the energetically demanding membrane trafficking, F-actin polymerization, and actomyosin machinery that mediate break down, remodeling, and movement through ECMs. Here, we provide an overview of the challenges of examining ATP generation and delivery within invading cells and how recent studies using diverse invasion models, experimental approaches, and energy biosensors are revealing that energy metabolism is an integral component of cell invasive behavior that is dynamically tuned to overcome the ECM environment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect