Pharmacokinetic Profile and Anti-Adhesive Effect of Oxaliplatin-PLGA Microparticle-Loaded Hydrogels in Rats for Colorectal Cancer Treatment

Autor:	Seung Hyuk Baik, Kyung Su Park, Jun Hyun Ahn, Sharif Md Abuzar, Sung Joo Hwang, Eun Jung Park
Rok vydání:	2019
Předmět:	Cmax lcsh:RS1-441 Pharmaceutical Science colorectal cancer 02 engineering and technology macromolecular substances Pharmacology Article lcsh:Pharmacy and materia medica 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacokinetics In vivo Hyaluronic acid Microparticle oxaliplatin technology industry and agriculture PLGA 021001 nanoscience & nanotechnology Bioavailability chemistry 030220 oncology & carcinogenesis Self-healing hydrogels intra-abdominal anti-adhesion barrier hydrogel 0210 nano-technology
Zdroj:	Pharmaceutics Pharmaceutics, Vol 11, Iss 8, p 392 (2019) Volume 11 Issue 8
ISSN:	1999-4923
Popis:	Colorectal cancer (CRC) is one of the most malignant and fatal cancers worldwide. Although cytoreductive surgery combined with chemotherapy is considered a promising therapy, peritoneal adhesion causes further complications after surgery. In this study, oxaliplatin-loaded Poly-(d,l-lactide-co-glycolide) (PLGA) microparticles were prepared using a double emulsion method and loaded into hyaluronic acid (HA)- and carboxymethyl cellulose sodium (CMCNa)-based cross-linked (HC) hydrogels. From characterization and evaluation study PLGA microparticles showed smaller particle size with higher entrapment efficiency, approximately 1100.4 ± 257.7 nm and 77.9 ± 2.8%, respectively. In addition, microparticle-loaded hydrogels showed more sustained drug release compared to the unloaded microparticles. Moreover, in an in vivo pharmacokinetic study after intraperitoneal administration in rats, a significant improvement in the bioavailability and the mean residence time of the microparticle-loaded hydrogels was observed. In HC21 hydrogels, AUC0&ndash 48h, Cmax, and Tmax were 16012.12 ± 188.75 ng· h/mL, 528.75 ± 144.50 ng/mL, and 1.5 h, respectively. Furthermore, experimental observation revealed that the hydrogel samples effectively protected injured tissues from peritoneal adhesion. Therefore, the results of the current pharmacokinetic study together with our previous report of the in vivo anti-adhesion efficacy of HC hydrogels demonstrated that the PLGA microparticle-loaded hydrogels offer novel therapeutic strategy for CRC treatment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ccd62316e729b9d1b529a8ac1f625cd https://pubmed.ncbi.nlm.nih.gov/31387217 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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