Inotropic and chronotropic actions of 2-substituted and 8-substituted derivatives of adenosine 3',5'-cyclic monophosphate
| Autor: | Norio Shimamoto, Kaoru Miura, Motohiko Kato, Nobuyuki Yamaji, Issei Matsubara, Shoichi Imai |
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| Rok vydání: | 1980 |
| Předmět: |
Male
Inotrope Chronotropic medicine.medical_specialty Chemistry Guinea Pigs Long-term potentiation General Chemistry General Medicine In Vitro Techniques 5 cyclic monophosphate Myocardial Contraction Adenosine Guinea pig Contractility Endocrinology Heart Rate Internal medicine Drug Discovery Cyclic AMP medicine Animals Female Aminophylline medicine.drug |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 28:1683-1687 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.28.1683 |
| Popis: | We synthesized several 2- and 8-substituted derivatives of adenosine 3', 5'-cyclic monophosphate (c-AMP), and examined the effects of these compounds on the isolated atrial muscle preparation of the guinea pig. We found that several 8-substituted c-AMPs could produce definite positive inotropic and chronotropic effects, even when applied from outside the cell, while all the 2-substituted c-AMPs produced negative inotropic and chronotropic effects. Pretreatment of the preparation with aminophylline resulted in a potentiation of the positive inotropic and chronotropic effects of 8-substituted c-AMPs, while the negative inotropic and chronotropic effects of 2-substituted c-AMPs were abolished. The mechanisms by which these effects were produced are discussed. |
| Databáze: | OpenAIRE |
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