Nifedipine and left ventricular function in beta-blocked patients
| Autor: | M S Ruttley, P I Joshi, D. J. Sheridan, Andrew H. Henderson, J J Dalal |
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| Rok vydání: | 1981 |
| Předmět: |
Inotrope
Male medicine.medical_specialty Cardiac output Sympathetic Nervous System Nifedipine Pyridines Heart Ventricles Hemodynamics Propanolamines Internal medicine Heart rate medicine Humans Ejection fraction business.industry Heart Middle Aged Atenolol medicine.anatomical_structure Anesthesia Depression Chemical Cardiology Vascular resistance Female Cardiology and Cardiovascular Medicine business medicine.drug Research Article |
| Zdroj: | British heart journal. 45(4) |
| ISSN: | 0007-0769 |
| Popis: | We studied the acute effects of nifedipine on left ventricular function and haemodynamics at constant heart rate in patients on beta-blocker therapy. Nifedipine significantly depressed left ventricular peak dP/dt and peak dP/dt x P-1. Nifedipine also significantly reduced systemic vascular resistance: this was associated with decreased systolic blood pressure and increased left ventricular stroke output, with slight non-significant increases of ejection fraction and mean circumferential shortening velocity. There was no change in left ventricular end-diastolic pressure. This clinical study shows that nifedipine increases cardiac output in association with arterial dilatation despite evidence for a negative inotropic effect. Such intrinsic negative inotropic effects would normally be masked by compensatory sympathetic activity. |
| Databáze: | OpenAIRE |
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