SERPINE1 -844 and -675 polymorphisms and chronic obstructive pulmonary disease in a Chinese Han population
| Autor: | Xiaopei Cui, Hongchao Wang, Hongyu Zhang, Haijun Li, Xia Xu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Pulmonary disease Gene Expression Single-nucleotide polymorphism Serpin Biochemistry Polymorphism Single Nucleotide 03 medical and health sciences chemistry.chemical_compound Pulmonary Disease Chronic Obstructive 0302 clinical medicine Chinese han population Asian People Gene Frequency Plasminogen Activator Inhibitor 1 Odds Ratio Medicine Humans Genetic Predisposition to Disease Chinese han Promoter Regions Genetic Alleles Aged COPD business.industry Chronic obstructive pulmonary disease Biochemistry (medical) Research Reports Cell Biology General Medicine Middle Aged single-nucleotide polymorphism medicine.disease 030104 developmental biology 030228 respiratory system chemistry Haplotypes Plasminogen activator inhibitor-1 Case-Control Studies Immunology plasminogen activator inhibitor-1 Female business Polymorphism Restriction Fragment Length Genome-Wide Association Study |
| Zdroj: | The Journal of International Medical Research |
| ISSN: | 1473-2300 |
| Popis: | ObjectiveTo investigate the association between serpin family E member 1 ( SERPINE1) -844 A/G and -675 4G/5G polymorphisms and chronic obstructive pulmonary disease (COPD) in a Chinese Han population.MethodSERPINE1 -844 A/G and -675 4G/5G polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism sequencing of genomic DNA from patients with COPD and healthy smoking controls.ResultsOut of 140 patients with COPD and 100 controls, all SERPINE1 -844 and -675 polymorphisms were in Hardy-Weinberg equilibrium. Differences in SERPINE1 -675 4G and 5G allele frequencies were statistically significant between the COPD and control groups (odds ratio [OR] 1.45, 95% confidence interval [CI] 1.00, 2.09), but there was no significant between-group difference in SERPINE1 -844 A and G allele frequencies. The SERPINE1 -675 4G/4G genotype was associated with COPD (OR 1.87, 95% CI 1.06, 3.32 [binary logistic regression]). Haplotype analysis showed that COPD was associated with SERPINE1 -844G/4G (OR 2.11, 95% CI 1.32, 3.38) and SERPINE1 -844G/5G (OR 0.66, 95% CI 0.45, 0.95).ConclusionThe SERPINE1 -675 polymorphism, but not SERPINE1 -844 polymorphism, was associated with susceptibility to COPD in a Chinese Han population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|