Structure-Based Model of RNA Pseudoknot Captures Magnesium-Dependent Folding Thermodynamics
| Autor: | José N. Onuchic, Ana Mandic, Ryan L. Hayes, Heiko Lammert, Ryan R. Cheng |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
RNA Folding
biology Chemistry Magnesium Beet western yellows virus Static Electricity Temperature chemistry.chemical_element biology.organism_classification Potassium Chloride Surfaces Coatings and Films Rna pseudoknot Folding (chemistry) Simple (abstract algebra) Luteovirus Materials Chemistry Nucleic Acid Conformation RNA Viral Thermodynamics Structure based Physical and Theoretical Chemistry Pseudoknot Biological system |
| Zdroj: | The Journal of Physical Chemistry B. 123:1505-1511 |
| ISSN: | 1520-5207 1520-6106 |
| DOI: | 10.1021/acs.jpcb.8b10791 |
| Popis: | We develop a simple, coarse-grained approach for simulating the folding of the Beet Western Yellow Virus (BWYV) pseudoknot toward the goal of creating a transferable model that can be used to study other small RNA molecules. This approach combines a structure-based model (SBM) of RNA with an electrostatic scheme that has previously been shown to correctly reproduce ionic condensation in the native basin. Mg |
| Databáze: | OpenAIRE |
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