Fungal Infections of the Stem Cell Transplant Recipient and Hematologic Malignancy Patients
| Autor: | Derek J. Bays, George Richard Thompson |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) medicine.medical_specialty medicine.medical_treatment 030106 microbiology Population Hematopoietic stem cell transplantation Aspergillosis 03 medical and health sciences 0302 clinical medicine Meta-Analysis as Topic Risk Factors Epidemiology Humans Medicine Candidiasis Invasive 030212 general & internal medicine education Intensive care medicine Immunosuppression Therapy Clinical Trials as Topic education.field_of_study Chemotherapy business.industry Mucormycosis Hematopoietic Stem Cell Transplantation Immunosuppression medicine.disease Infectious Diseases Hematologic Neoplasms Stem cell business Invasive Fungal Infections Systematic Reviews as Topic |
| Zdroj: | Infectious Disease Clinics of North America. 33:545-566 |
| ISSN: | 0891-5520 |
| DOI: | 10.1016/j.idc.2019.02.006 |
| Popis: | Despite advances in chemotherapy and supportive care, morbidity and mortality remain high for patients with hematologic malignancies (HMs). Those who require hematopoietic stem cell transplantation (HSCT) often require significant immunosuppression and are subject to a variety of complications. These patients carry multiple risk factors for infectious complications, including the development of invasive fungal infections, compared with the general population. Because antifungal prophylaxis has been widely adopted, there has been a shift away from invasive candidiasis toward invasive mold infections, including breakthrough infections. For patients with HM and HSCT, we outline the epidemiology, manifestations, diagnosis, and treatment of invasive fungal infections. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|