Effects of Sub-Lethal Doses of Selenium Nanoparticles on the Health Status of Rats
| Autor: | Pavel Horky, Magdalena Pribilova, Lenka Urbankova, Sylvie Skalickova, Jiri Skladanka, Andrea Ridošková, Pavlína Pelcová |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Health Toxicology and Mutagenesis chemistry.chemical_element Toxicology lcsh:Chemical technology Article Superoxide dismutase 03 medical and health sciences Internal medicine medicine lcsh:TP1-1185 glucose glutathione peroxidase nanotoxicity liver enzymes histopathology diet growth performance superoxide dismutase 030304 developmental biology chemistry.chemical_classification 0303 health sciences Chemical Health and Safety biology Chemistry Glutathione peroxidase 0402 animal and dairy science 04 agricultural and veterinary sciences 040201 dairy & animal science Antioxidant capacity Endocrinology medicine.anatomical_structure biology.protein Duodenum Alkaline phosphatase Histopathology medicine.symptom Weight gain Selenium |
| Zdroj: | Toxics, Vol 9, Iss 28, p 28 (2021) Toxics Toxics; Volume 9; Issue 2; Pages: 28 |
| ISSN: | 2305-6304 |
| Popis: | Selenium nanoparticles (SeNPs) are fast becoming a key instrument in several applications such as medicine or nutrition. Questions have been raised about the safety of their use. Male rats were fed for 28 days on a monodiet containing 0.5, 1.5, 3.0 and 5.0 mg Se/kg. Se content in blood and liver, liver panel tests, blood glucose, total antioxidant capacity (TAC), the activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were analysed. Liver and duodenum were subjected to histopathology examination. The weight gain of rats showed no differences between tested groups. Se content in blood was higher in all treated groups compared to the control group. The liver concentration of Se in the treated groups varied in the range from 222 to 238 ng/g. No differences were observed in the activity of AST (aspartate aminotransferase), ALP (alkaline phosphatase) and TAS (total antioxidant status). A significant decrease in ALT activity compared to the control group was observed in the treated groups. GPx activity varied from 80 to 88 U/mL through tested groups. SOD activity in liver was decreased in the SeNP-treated group with 5 mg Se/kg (929 ± 103 U/mL). Histopathological examination showed damage to the liver parenchyma and intestinal epithelium in a dose-dependent manner. This study suggests that short-term SeNP supplementation can be safe and beneficial in Se deficiency or specific treatment. |
| Databáze: | OpenAIRE |
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