Seroprevalence of Toxoplasma gondii infection among patients with hand, foot and mouth disease in Henan, China: a hospital-based study
| Autor: | Shuai Wang, Luwen Zhang, Dong Wang, Shiguo Liu, Haizhu Zhang, Jiarong Deng, Jingbo Ma, Zhijun Yao, Chunwei Lan |
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| Jazyk: | angličtina |
| Předmět: |
Male
medicine.medical_specialty China Short Report Antibodies Protozoan Toxoplasma gondii Seroprevalence Enzyme-Linked Immunosorbent Assay Severity of Illness Index stomatognathic system Seroepidemiologic Studies Internal medicine Epidemiology parasitic diseases medicine Prevalence Animals Humans Child biology Foot-and-mouth disease business.industry Coinfection Public Health Environmental and Occupational Health Case-control study Infant General Medicine biology.organism_classification medicine.disease Hand Toxoplasmosis Foot and mouth disease Hospitalization Infectious Diseases Case-Control Studies Child Preschool Immunoglobulin G Tropical medicine Immunology Cats Female business Hand Foot and Mouth Disease Toxoplasma |
| Zdroj: | Infectious Diseases of Poverty |
| ISSN: | 2049-9957 |
| DOI: | 10.1186/s40249-015-0088-3 |
| Popis: | Background The prevalence of infection with Toxoplasma gondii (T. gondii) in humans has been increasing in China due to the growing number of cats in the country. Hand, foot and mouth disease (HFMD) is a serious public health issue in China and still one of the leading causes of child mortality. However, little is known about the epidemiology of T. gondii infection among HFMD patients. Methods A case–control study of 281 HFMD patients from the First People’s Hospital of Pingdingshan in Pingdingshan city, Henan province, central China, and 222 controls from Pingdingshan city was conducted. Anti-T. gondii antibodies were serologically detected using the enzyme-linked immunosorbent assay. Results We found that the overall anti-T. gondii immunoglobulin G (IgG) antibody prevalence among HFMD patients was 12.46 %, which was significantly higher than that in clinically healthy children (1.80 %). The highest T. gondii seroprevalence was detected in critical cases (22.58 %), followed by severe cases (11.50 %), and the lowest was detected in mild cases (8.33 %). Conclusion The present study is the first survey of T. gondii seroprevalence among HFMD patients in China; 12.46 % were defined as seropositive. It is imperative that improved integrated measures are taken to prevent and control T. gondii infection among HFMD patients. Electronic supplementary material The online version of this article (doi:10.1186/s40249-015-0088-3) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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