Intra- and interhemispheric white matter tract associations with auditory spatial processing: Distinct normative and aging effects
| Autor: | Jens H. Jensen, Mark A. Eckert, Carolyn M. McClaskey, Kelly C. Harris, James W. Dias |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Aging Cognitive Neuroscience Corpus callosum Posterior parietal cortex Speech in noise Article 050105 experimental psychology Superior longitudinal fasciculus lcsh:RC321-571 White matter Young Adult 03 medical and health sciences Spatial Processing 0302 clinical medicine Audiometry Arcuate fasciculus Neural Pathways Fractional anisotropy medicine Humans 0501 psychology and cognitive sciences Spatial analysis lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Aged Auditory spatial attention Aged 80 and over Cued speech 05 social sciences Brain Auditory spatial processing Middle Aged White Matter Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Neurology Auditory Perception Speech Perception Female Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | NeuroImage, Vol 215, Iss, Pp 116792-(2020) NeuroImage |
| ISSN: | 1095-9572 |
| Popis: | Declining auditory spatial processing is hypothesized to contribute to the difficulty older adults have detecting, locating, and selecting a talker from among others in noisy listening environments. Though auditory spatial processing has been associated with several cortical structures, little is known regarding the underlying white matter architecture or how age-related changes in white matter microstructure may affect it. The arcuate fasciculus is a target for understanding age-related differences in auditory spatial attention based on normative spatial attention findings in humans. Similarly, animal and human clinical studies suggest that the corpus callosum plays a role in the cross-hemispheric integration of auditory spatial information important for spatial localization and attention. The current investigation used diffusion imaging to examine the extent to which age-group differences in the identification of spatially cued speech were accounted for by individual differences in the white matter microstructure of the right arcuate fasciculus and the corpus callosum. Higher right arcuate and callosal fractional anisotropy (FA) predicted better segregation and identification of spatially cued speech across younger and older listeners. Further, individual differences in callosal microstructure mediated age-group differences in auditory spatial processing. Follow-up analyses suggested that callosal tracts connecting left and right pre-frontal and posterior parietal cortex are particularly important for auditory spatial processing. The results are consistent with previous work in animals and clinical human samples and provide a cortical mechanism to account for age-related deficits in auditory spatial processing. Further, the results suggest that both intrahemispheric and interhemispheric mechanisms are involved in auditory spatial processing. |
| Databáze: | OpenAIRE |
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