Lipid Nanovectors to Deliver RNA Oligonucleotides in Cancer
| Autor: | Giuseppe De Rosa, Sara Lusa, Virginia Campani, Giuseppina Salzano |
|---|---|
| Přispěvatelé: | Campani, Virginia, Salzano, Giuseppina, Lusa, Sara, DE ROSA, Giuseppe |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Small interfering RNA lipid-nanoparticle micelles General Chemical Engineering Review 02 engineering and technology Computational biology Biology cationic liposomes lcsh:Chemistry 03 medical and health sciences cationic liposome microRNA Gene silencing General Materials Science Regulation of gene expression Oligonucleotide RNA lipid-nanoparticles 021001 nanoscience & nanotechnology Non-coding RNA nucleic acid stable nucleic acid lipid particles (SNALPs) 030104 developmental biology Biopharmaceutical Biochemistry lcsh:QD1-999 0210 nano-technology |
| Zdroj: | Nanomaterials, Vol 6, Iss 7, p 131 (2016) Nanomaterials |
| ISSN: | 2079-4991 |
| Popis: | The growing knowledge on the mechanisms of gene silencing and gene regulation by non-coding RNAs (ncRNA), mainly small interfering RNA (siRNA) and microRNA (miRNA), is providing a significant boost to the development of new therapeutic strategies for the treatment of cancer. However, the design of RNA-based therapeutics is hampered by biopharmaceutical issues, thus requiring the use of suitable delivery strategies. In this regards, lipid nanovectors have been successfully investigated to deliver RNA in different forms of cancer. Compared to other biomaterials, lipids offer advantages such as biocompatibility, biodegradability, easy production, low cost, limited toxicity and immunogenicity. The possibility to formulate these materials in the form of nanovectors allows overcoming biopharmaceutical issues associated to the therapeutic use of RNA, with the possibility to target tumors. This review takes stock of the main lipid nanovectors proposed to deliver ncRNA. For each considered delivery strategy, the rational design and the most meaningful in vitro and in vivo results are reported and discussed. |
| Databáze: | OpenAIRE |
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