Local Analysis of Heterogeneous Intracellular Transport: Slow and Fast moving Endosomes
| Autor: | Daniel Han, Alessandro Taloni, Thomas A. Waigh, Gianni Pagnini, Nickolay Korabel, Sergei Fedotov, Viki Allan |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Quantitative Biology - Subcellular Processes
Anomalous diffusion Science QC1-999 General Physics and Astronomy FOS: Physical sciences Tracking (particle physics) Astrophysics 01 natural sciences Power law Article 010305 fluids & plasmas Quantitative Biology::Subcellular Processes Position (vector) anomalous diffusion 0103 physical sciences Statistical physics heterogeneous Diffusion (business) 010306 general physics Subcellular Processes (q-bio.SC) Condensed Matter - Statistical Mechanics Physics Fractional Brownian motion Statistical Mechanics (cond-mat.stat-mech) endosomes Exponential function QB460-466 Local analysis FOS: Biological sciences |
| Zdroj: | Entropy Entropy, Vol 23, Iss 958, p 958 (2021) Volume 23 Issue 8 Korabel, N, Han, D, Taloni, A, Pagnini, G, Fedotov, S, Allan, V & Waigh, T A 2021, ' Local Analysis of Heterogeneous Intracellular Transport: Slow and Fast Moving Endosomes ', Entropy, vol. 23, no. 8, 958 . https://doi.org/10.3390/e23080958 Entropy (Basel, Online) 23 (2021): 958-1–958-15. doi:10.3390/e23080958 info:cnr-pdr/source/autori:Korabel N.; Han D.; Taloni A.; Pagnini G.; Fedotov S.; Allan V.; Waigh T.A./titolo:Local analysis of heterogeneous intracellular transport: Slow and fast moving endosomes/doi:10.3390%2Fe23080958/rivista:Entropy (Basel, Online)/anno:2021/pagina_da:958-1/pagina_a:958-15/intervallo_pagine:958-1–958-15/volume:23 |
| Popis: | Trajectories of endosomes inside living eukaryotic cells are highly heterogeneous in space and time and diffuse anomalously due to a combination of viscoelasticity, caging, aggregation and active transport. Some of the trajectories display switching between persistent and anti-persistent motion while others jiggle around in one position for the whole measurement time. By splitting the ensemble of endosome trajectories into slow moving sub-diffusive and fast moving super-diffusive endosomes, we analyzed them separately. The mean squared displacements and velocity auto-correlation functions confirm the effectiveness of the splitting methods. Applying the local analysis, we show that both ensembles are characterized by a spectrum of local anomalous exponents and local generalized diffusion coefficients. Slow and fast endsomes have exponential distributions of local anomalous exponents and power law distributions of generalized diffusion coefficients. This suggests that heterogeneous fractional Brownian motion is an appropriate model for both fast and slow moving endosomes. This article is part of a Special Issue entitled: "Recent Advances In Single-Particle Tracking: Experiment and Analysis" edited by Janusz Szwabi\'nski and Aleksander Weron. Comment: 11 pages, 6 figures |
| Databáze: | OpenAIRE |
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