A validation study of the Ursodeoxycholic Acid Response Score in Japanese patients with primary biliary cholangitis

Autor:	Satoru Joshita, Mie Inao, Kazuhito Kawata, Mie Arakawa, Toshihiko Arizumi, Tadashi Namisaki, Norifumi Kawada, Minami Yagi, Atsushi Tanaka, Akira Kaneko, Keisuke Kakisaka, Kentaro Kikuchi, Takeji Umemura, Akira Honda, Kosuke Matsumoto, Jong-Hon Kang, Mitsuhiko Aiso, Satoshi Mochida, Hideki Fujii, Yamato Tamura, Naoaki Hashimoto, Masashi Ninomiya, Atsumasa Komori, Jun Itakura, Tsutomu Masaki, Takako Nomura, Atsushi Takahashi, Masaaki Takamura, Hajime Takikawa, Ryo Miura, Hitoshi Yoshiji, Hiromasa Ohira, Masanori Abe, Yasuhiro Takikawa, Ken Sato, Yoshinari Asaoka
Rok vydání:	2020
Předmět:	Male Cholagogues and Choleretics medicine.medical_specialty Validation study Combination therapy Gastroenterology Japan Interquartile range Internal medicine medicine Humans In patient Aged Bezafibrate Hepatology Receiver operating characteristic Liver Cirrhosis Biliary business.industry Ursodeoxycholic Acid Middle Aged Alkaline Phosphatase Confidence interval Ursodeoxycholic acid Female business medicine.drug
Zdroj:	Liver International. 40:1926-1933
ISSN:	1478-3231 1478-3223
DOI:	10.1111/liv.14534
Popis:	BACKGROUND/PURPOSE Although ursodeoxycholic acid (UDCA) is a first-line treatment for primary biliary cholangitis (PBC), 20%-30% of patients with PBC exhibit an incomplete response to UDCA. Recently, the UDCA Response Score was proposed for predicting response to UDCA using pretreatment parameters in patients with PBC. We aimed to validate the UDCA Response Score in Japanese patients with PBC. METHODS Registry data of Japanese patients (n = 873) were collected. Patients with data on all clinical parameters required for calculating the UDCA Response Score were selected. The endpoint was UDCA response, defined as alkaline phosphatase
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc24245db4c586a96a5fd94b77c3e24 https://doi.org/10.1111/liv.14534 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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