The search for novel treatment strategies for Streptococcus pneumoniae infections
| Autor: | Freya Cools, Paul Cos, Peter Delputte |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.drug_class
Virulence Factors medicine.medical_treatment Antibiotics Virulence Review Article Biology medicine.disease_cause Microbiology Pneumococcal Infections antibiotics 03 medical and health sciences Immune system Streptococcus pneumoniae medicine Humans 030304 developmental biology 0303 health sciences AcademicSubjects/SCI01150 030306 microbiology Pharmacology. Therapy Bacterial pneumonia Immunotherapy medicine.disease drug development Anti-Bacterial Agents virulence Pneumococcal infections Infectious Diseases Drug development novel drug targets Immunology Human medicine immunotherapy |
| Zdroj: | FEMS Microbiology Reviews FEMS microbiology: reviews |
| ISSN: | 1574-6976 0168-6445 |
| Popis: | This review provides an overview of the most important novel treatment strategies against Streptococcus pneumoniae infections published over the past 10 years. The pneumococcus causes the majority of community-acquired bacterial pneumonia cases, and it is one of the prime pathogens in bacterial meningitis. Over the last 10 years, extensive research has been conducted to prevent severe pneumococcal infections, with a major focus on (i) boosting the host immune system and (ii) discovering novel antibacterials. Boosting the immune system can be done in two ways, either by actively modulating host immunity, mostly through administration of selective antibodies, or by interfering with pneumococcal virulence factors, thereby supporting the host immune system to effectively overcome an infection. While several of such experimental therapies are promising, few have evolved to clinical trials. The discovery of novel antibacterials is hampered by the high research and development costs versus the relatively low revenues for the pharmaceutical industry. Nevertheless, novel enzymatic assays and target-based drug design, allow the identification of targets and the development of novel molecules to effectively treat this life-threatening pathogen. This review discusses recent progress in anti-pneumococcal treatment strategies, with a focus on novel drug targets. |
| Databáze: | OpenAIRE |
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