Comparison of 2 Different Methods of Transepithelial Corneal Collagen Cross-Linking: Analysis of Corneal Histology and Hysteresis
| Autor: | Ho Yoon Kim, Jong Soo Lee, Young Min Park |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Intraocular pressure genetic structures Ultraviolet Rays Corneal Stroma Riboflavin Corneal collagen cross-linking Corneal Keratocytes Biology Cornea Corneal hysteresis 03 medical and health sciences 0302 clinical medicine Stroma Ophthalmology In Situ Nick-End Labeling medicine Animals New zealand white Intraocular Pressure Microscopy Confocal Photosensitizing Agents Epithelium Corneal Histology Ultraviolet a eye diseases Surgery Cross-Linking Reagents 030104 developmental biology Photochemotherapy 030221 ophthalmology & optometry Collagen Rabbits sense organs After treatment Dilatation Pathologic |
| Zdroj: | Cornea. 36:860-865 |
| ISSN: | 0277-3740 |
| Popis: | Purpose To compare the effect of 2 different methods of transepithelial corneal collagen cross-linking (CXL) on corneal histology and hysteresis. Methods The right eyes of New Zealand white rabbits (n = 50) were treated using one of the 2 transepithelial CXL methods. The eyes were then divided into 2 groups: group 1, transepithelial CXL using continuous ultraviolet A (UVA); group 2, accelerated transepithelial CXL using pulsed UVA. Results Both groups showed a postoperative increase in central corneal thickness. In both groups, an increase in corneal hysteresis was found after CXL, but the changes were not significant when compared with the baseline value. The corneal resistance factor and corneal-compensated intraocular pressure also remained unchanged in both groups after treatment. In both groups, the CXL effect reached the anterior-mid part of the corneal stroma. In group 1, CXL mostly affected the anterior-mid part stroma, whereas group 2 showed stromal keratocyte loss, and an acellular zone, in the deep stroma. More signs of keratocyte apoptosis were observed in group 2 than in group 1. Conclusions Accelerated transepithelial CXL using pulsed UVA showed considerably deeper effect in the stroma with keratocyte loss than transepithelial CXL using continuous UVA. |
| Databáze: | OpenAIRE |
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