Association between Allogeneic or Autologous Blood Transfusion and Survival in Patients after Radical Prostatectomy: A Systematic Review and Meta-Analysis
| Autor: | Yun Ye, Xiao-Hua Yuan, Su-Liang Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Blood transfusion Research Facilities Physiology medicine.medical_treatment Libraries lcsh:Medicine 030204 cardiovascular system & hematology Cochrane Library Information Centers Gastroenterology Database and Informatics Methods Blood Transfusion Autologous 0302 clinical medicine Mathematical and Statistical Techniques Medicine and Health Sciences Reproductive System Procedures Database Searching lcsh:Science Multidisciplinary Prostatectomy Prostate Cancer Hazard ratio Prostate Diseases Hematology Research Assessment Clinical Laboratory Sciences Radical Prostatectomy Body Fluids Blood Treatment Outcome Oncology 030220 oncology & carcinogenesis Meta-analysis Physical Sciences Anatomy Statistics (Mathematics) Research Article medicine.medical_specialty Systematic Reviews Urology Surgical and Invasive Medical Procedures Research and Analysis Methods Disease-Free Survival 03 medical and health sciences Diagnostic Medicine Internal medicine medicine Humans Transplantation Homologous Blood Transfusion Statistical Methods Surgical Excision business.industry Transfusion Medicine lcsh:R Cancers and Neoplasms Biology and Life Sciences Prostatic Neoplasms Perioperative Models Theoretical Confidence interval Surgery Transplantation Genitourinary Tract Tumors lcsh:Q Neoplasm Recurrence Local business Publication Bias Mathematics Meta-Analysis |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 1, p e0171081 (2017) |
| ISSN: | 1932-6203 |
| Popis: | BACKGROUND A number of studies have investigated the effect of perioperative blood transfusion (PBT) for patients after radical prostatectomy (RP), with some reporting conflicting results. A systematic review of the literature and a meta-analysis were conducted to explore the association between PBT (autologous or allogeneic) and biochemical recurrence-free survival (BRFS), overall survival (OS) and cancer-specific survival (CSS) in patients undergoing RP. METHODS The PubMed, Medline, Cochrane Library, and Embase databases were searched for published controlled clinical studies on perioperative allogeneic or autologous blood transfusion (BT) and patient survival after RP. STATA software version 12.0 was used for data analysis. We used hazard ratios (HRs) and 95% confidence intervals (CIs) to test the correlation between BT and patient survival after RP. RESULTS Data from a total of 26,698 patients in ten published studies were included in the meta-analysis. The meta-analysis results showed that autologous BT was not associated with BRFS (HR: 1.06; 95% CI: 0.96-1.18; Z = 1.17; P = 0.24), OS (HR: 0.86; 95% CI: 0.71-1.04; Z = 1.58; P = 0.11), or CSS (HR: 0.98; 95% CI: 0.49-1.96; Z = 0.05; P = 0.96). Allogeneic BT exhibited a significant association with worse BRFS (HR: 1.09; 95% CI: 1.01-1.16; Z = 2.37; P = 0.02), OS (HR: 1.43; 95% CI: 1.24-1.64; Z = 4.95; P |
| Databáze: | OpenAIRE |
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