NK cells adjuvant therapy shows survival benefits in a gastric mixed signet ring cell carcinoma patient

Autor: Yuanyuan Jin, Zheng-Yang Sun, Wen-Zhuo Yang, Jian Chen, Zhong-Bo Wang, Zhaoyong Yang, Chun-Tao Wu
Rok vydání: 2021
Předmět:
Adult
medicine.medical_specialty
medicine.medical_treatment
gastric signet ring cell carcinoma
chemotherapy
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Gastrectomy
Stomach Neoplasms
distal gastrectomy
Internal medicine
Signet ring cell carcinoma
medicine
Adjuvant therapy
Carcinoma
Humans
Transplantation
Homologous
Antigens
Tumor-Associated
Carbohydrate
Clinical Case Report
030212 general & internal medicine
Neoplasm Staging
Postoperative Care
Chemotherapy
Signet ring cell
business.industry
Cancer
General Medicine
Prognosis
medicine.disease
Combined Modality Therapy
Oxaliplatin
Killer Cells
Natural
natural killer cells adjuvant therapy
Treatment Outcome
tumor markers
030220 oncology & carcinogenesis
Adenocarcinoma
Female
business
Carcinoma
Signet Ring Cell
Research Article
medicine.drug
Zdroj: Medicine
ISSN: 1536-5964
0025-7974
DOI: 10.1097/md.0000000000024979
Popis: Rationale: Advanced signet ring cell (SRC) carcinoma has a worse prognosis. Therefore, early diagnosis and prevention is particularly important; SRC tumors have lower R0 resection rate and are thought to be less chemosensitive than non-SRCC. Consequently, a novel postoperative adjuvant treatment is urgently needed to improve clinical outcomes. Patient concerns: A 41-year-old female with advanced gastric SRC carcinoma was treated with radical gastrectomy and oxaliplatin-based regimen for 6 cycles after surgery. She was suspected of recurrence with the high level of carbohydrate antigen (CA) 72-4. Diagnoses: The gastroscopy revealed SRC carcinoma of gastric antrum and poorly differentiated adenocarcinoma in some areas. The diagnosis of postoperative pathology report was gastric cancer with stage III C (T4a, N3a, M0). Interventions: The level of CA72-4 rapidly increased during the 2 follow-up after the completion of conventional treatment, ex vivo-cultured allogeneic natural killer (NK) cell infusion was offered to prevent recurrence. Outcomes: Intravenous injections of NK cells combination with surgical treatment and chemotherapy showed therapeutic effects in this patient with possible relapse. The patient remained disease-free 46 months after the infusion of NK cells until the latest follow-up. Lessons: CA72-4 appeared to be the most sensitive and specific marker in the gastric cancer patient, and the high level of CA72-4 may indicate the risk of recurrence. This case report provide rationale for NK cell infusion following the rapid increase of CA72-4 to prevent recurrence.
Databáze: OpenAIRE
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