Methylphenidate enhances acquisition and retention of spatial memory
| Autor: | Stephan G. Anagnostaras, Stephanie A. Carmack, Carina L. Block, Kristin K. Howell |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Fear memory Mouse Conditioning Classical Hippocampus Morris water navigation task Fear conditioning Water maze Mice Memory Orientation medicine Psychology Animals Maze Learning Methylphenidate General Neuroscience Neurosciences Retention Psychology Fear Memory retention Classical Psychostimulant Retention (Psychology) Cognitive Sciences Central Nervous System Stimulants Female Memory acquisition Conditioning Cognitive enhancement Cognitive psychology medicine.drug |
| Zdroj: | Carmack, SA; Block, CL; Howell, KK; & Anagnostaras, SG. (2014). Methylphenidate enhances acquisition and retention of spatial memory. Neuroscience Letters, 567, 45-50. doi: 10.1016/j.neulet.2014.03.029. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/9kp4x2f5 Neuroscience letters, vol 567 |
| DOI: | 10.1016/j.neulet.2014.03.029. |
| Popis: | Psychostimulants containing methylphenidate (MPH) are increasingly being used both on and off-label to enhance learning and memory. Still, almost no studies have investigated MPH's ability to specifically improve spatial or long-term memory. Here we examined the effect of training with 1 or 10. mg/kg MPH on hidden platform learning in the Morris water maze. 10. mg/kg MPH improved memory acquisition and retention, while 1. mg/kg MPH improved memory retention. Taken together with prior evidence that low, clinically relevant, doses of MPH (0.01-1. mg/kg MPH) enhance fear memory we conclude that MPH broadly enhances memory. © 2014 Elsevier Ireland Ltd. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|